Search Results

Overview

Uniprot IDQ9BXF6
Protein NameRab11 family-interacting protein 5
Gene NameRAB11FIP5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
192 KPRSPFSKIRDKMKG
232 LGKMGKAKGFFLRNK
586 MVDTKRLKDSAVLDQ

Function

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis

Protein Sequence

10 MALVRGAEPA 20 AGPSRWLPTH 30 VQVTVLRARG 40 LRGKSSGAGS 50 TSDAYTVIQV 60 GREKYSTSVV 70 EKTHGCPEWR 80 EECSFELPPG 90 ALDGLLRAQE 100 ADAGPAPWAA 110 SSAAACELVL 120 TTMHRSLIGV 130 DKFLGQATVA 140 LDEVFGAGRA 150 QHTQWYKLHS 160 KPGKKEKERG 170 EIEVTIQFTR 180 NNLSASMFDL 190 SMKDKPRSPF 200 SKIRDKMKGK 210 KKYDLESASA 220 ILPSSAIEDP 230 DLGSLGKMGK 240 AKGFFLRNKL 250 RKSSLTQSNT 260 SLGSDSTLSS 270 ASGSLAYQGP 280 GAELLTRSPS 290 RSSWLSTEGG 300 RDSAQSPKLF 310 THKRTYSDEA 320 NQMRVAPPRA 330 LLDLQGHLDA 340 ASRSSLCVNG 350 SHIYNEEPQG 360 PVRHRSSISG 370 SLPSSGSLQA 380 VSSRFSEEGP 390 RSTDDTWPRG 400 SRSNSSSEAV 410 LGQEELSAQA 420 KVLAPGASHP 430 GEEEGARLPE 440 GKPVQVATPI 450 VASSEAVAEK 460 EGARKEERKP 470 RMGLFHHHHQ 480 GLSRSELGRR 490 SSLGEKGGPI 500 LGASPHHSSS 510 GEEKAKSSWF 520 GLREAKDPTQ 530 KPSPHPVKPL 540 SAAPVEGSPD 550 RKQSRSSLSI 560 ALSSGLEKLK 570 TVTSGSIQPV 580 TQAPQAGQMV 590 DTKRLKDSAV 600 LDQSAKYYHL 610 THDELISLLL 620 QRERELSQRD 630 EHVQELESYI 640 DRLLVRIMET 650 SPTLLQIPPG PPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005769 early endosome
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0055038 recycling endosome membrane
Cellular Component GO:0030141 secretory granule
Cellular Component GO:0030658 transport vesicle membrane
Molecular Function GO:0043015 gamma-tubulin binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0071468 cellular response to acidic pH
Biological Process GO:0035773 insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0070164 negative regulation of adiponectin secretion
Biological Process GO:0045055 regulated exocytosis
Biological Process GO:2000008 regulation of protein localization to cell surface

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.