Search Results
Overview
| Uniprot ID | Q9BXI6 |
|---|---|
| Protein Name | TBC1 domain family member 10A |
| Gene Name | TBC1D10A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 422 | DAPLPGSKAKPKPPK |
| 424 | PLPGSKAKPKPPKQA |
Function
GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811)
Protein Sequence
10
MAKSNGENGP
20
RAPAAGESLS
30
GTRESLAQGP
40
DAATTDELSS
50
LGSDSEANGF
60
AERRIDKFGF
70
IVGSQGAEGA
80
LEEVPLEVLR
90
QRESKWLDML
100
NNWDKWMAKK
110
HKKIRLRCQK
120
GIPPSLRGRA
130
WQYLSGGKVK
140
LQQNPGKFDE
150
LDMSPGDPKW
160
LDVIERDLHR
170
QFPFHEMFVS
180
RGGHGQQDLF
190
RVLKAYTLYR
200
PEEGYCQAQA
210
PIAAVLLMHM
220
PAEQAFWCLV
230
QICEKYLPGY
240
YSEKLEAIQL
250
DGEILFSLLQ
260
KVSPVAHKHL
270
SRQKIDPLLY
280
MTEWFMCAFS
290
RTLPWSSVLR
300
VWDMFFCEGV
310
KIIFRVGLVL
320
LKHALGSPEK
330
VKACQGQYET
340
IERLRSLSPK
350
IMQEAFLVQE
360
VVELPVTERQ
370
IEREHLIQLR
380
RWQETRGELQ
390
CRSPPRLHGA
400
KAILDAEPGP
410
RPALQPSPSI
420
RLPLDAPLPG
430
SKAKPKPPKQ
440
AQKEQRKQMK
450
GRGQLEKPPA
460
PNQAMVVAAA
470
GDACPPQHVP
480
PKDSAPKDSA
490
PQDLAPQVSA
500
HHRSQESLTS
QESEDTYL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Biological Process | GO:0045862 | positive regulation of proteolysis |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0045296 | cadherin binding |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.