Search Results

Overview

Uniprot IDQ9BXJ9
Protein NameN-alpha-acetyltransferase 15, NatA auxiliary subunit
Gene NameNAA15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
320 FLRMNFSKGCPPVFN
605 KQRRAQKKAQIEEEK
62 TLNCLGKKEEAYELV

Function

Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306)

Protein Sequence

10 MPAVSLPPKE 20 NALFKRILRC 30 YEHKQYRNGL 40 KFCKQILSNP 50 KFAEHGETLA 60 MKGLTLNCLG 70 KKEEAYELVR 80 RGLRNDLKSH 90 VCWHVYGLLQ 100 RSDKKYDEAI 110 KCYRNALKWD 120 KDNLQILRDL 130 SLLQIQMRDL 140 EGYRETRYQL 150 LQLRPAQRAS 160 WIGYAIAYHL 170 LEDYEMAAKI 180 LEEFRKTQQT 190 SPDKVDYEYS 200 ELLLYQNQVL 210 REAGLYREAL 220 EHLCTYEKQI 230 CDKLAVEETK 240 GELLLQLCRL 250 EDAADVYRGL 260 QERNPENWAY 270 YKGLEKALKP 280 ANMLERLKIY 290 EEAWTKYPRG 300 LVPRRLPLNF 310 LSGEKFKECL 320 DKFLRMNFSK 330 GCPPVFNTLR 340 SLYKDKEKVA 350 IIEELVVGYE 360 TSLKSCRLFN 370 PNDDGKEEPP 380 TTLLWVQYYL 390 AQHYDKIGQP 400 SIALEYINTA 410 IESTPTLIEL 420 FLVKAKIYKH 430 AGNIKEAARW 440 MDEAQALDTA 450 DRFINSKCAK 460 YMLKANLIKE 470 AEEMCSKFTR 480 EGTSAVENLN 490 EMQCMWFQTE 500 CAQAYKAMNK 510 FGEALKKCHE 520 IERHFIEITD 530 DQFDFHTYCM 540 RKITLRSYVD 550 LLKLEDVLRQ 560 HPFYFKAARI 570 AIEIYLKLHD 580 NPLTDENKEH 590 EADTANMSDK 600 ELKKLRNKQR 610 RAQKKAQIEE 620 EKKNAEKEKQ 630 QRNQKKKKDD 640 DDEEIGGPKE 650 ELIPEKLAKV 660 ETPLEEAIKF 670 LTPLKNLVKN 680 KIETHLFAFE 690 IYFRKEKFLL 700 MLQSVKRAFA 710 IDSSHPWLHE 720 CMIRLFNTAV 730 CESKDLSDTV 740 RTVLKQEMNR 750 LFGATNPKNF 760 NETFLKRNSD 770 SLPHRLSAAK 780 MVYYLDPSSQ 790 KRAIELATTL 800 DESLTNRNLQ 810 TCMEVLEALY 820 DGSLGDCKEA 830 AEIYRANCHK 840 LFPYALAFMP 850 PGYEEDMKIT 860 VNGDSSAEAE ELANEI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0031415 NatA complex
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0010698 acetyltransferase activator activity
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0051604 protein maturation
Biological Process GO:0050821 protein stabilization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.