Overview
| Uniprot ID | Q9BXN1 |
|---|
| Protein Name | Asporin |
|---|
| Gene Name | ASPN |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
MLDLQNNKIKEIKEN |
| 118 |
NNKIKEIKENDFKGL |
| 123 |
EIKENDFKGLTSLYG |
| 137 |
GLILNNNKLTKIHPK |
| 140 |
LNNNKLTKIHPKAFL |
| 150 |
PKAFLTTKKLRRLYL |
| 171 |
EIPLNLPKSLAELRI |
| 182 |
ELRIHENKVKKIQKD |
| 188 |
NKVKKIQKDTFKGMN |
| 231 |
HIRIAEAKLTSVPKG |
| 237 |
AKLTSVPKGLPPTLL |
| 262 |
TVELEDFKRYKELQR |
| 276 |
RLGLGNNKITDIENG |
| 300 |
EIHLENNKLKKIPSG |
| 303 |
LENNKLKKIPSGLPE |
| 338 |
DFCPTVPKMKKSLYS |
Function
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity
Protein Sequence
10
MKEYVLLLFL
20
ALCSAKPFFS
30
PSHIALKNMM
40
LKDMEDTDDD
50
DDDDDDDDDD
60
DEDNSLFPTR
70
EPRSHFFPFD
80
LFPMCPFGCQ
90
CYSRVVHCSD
100
LGLTSVPTNI
110
PFDTRMLDLQ
120
NNKIKEIKEN
130
DFKGLTSLYG
140
LILNNNKLTK
150
IHPKAFLTTK
160
KLRRLYLSHN
170
QLSEIPLNLP
180
KSLAELRIHE
190
NKVKKIQKDT
200
FKGMNALHVL
210
EMSANPLDNN
220
GIEPGAFEGV
230
TVFHIRIAEA
240
KLTSVPKGLP
250
PTLLELHLDY
260
NKISTVELED
270
FKRYKELQRL
280
GLGNNKITDI
290
ENGSLANIPR
300
VREIHLENNK
310
LKKIPSGLPE
320
LKYLQIIFLH
330
SNSIARVGVN
340
DFCPTVPKMK
350
KSLYSAISLF
360
NNPVKYWEMQ
370
PATFRCVLSR
380
MSVQLGNFGM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0140150 |
gel phase of interstitial matrix |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Biological Process |
GO:0030282 |
bone mineralization |
| Biological Process |
GO:0070171 |
negative regulation of tooth mineralization |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:1902617 |
response to fluoride |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.