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Overview

Uniprot IDQ9BXT6
Protein NameRNA helicase Mov10l1
Gene NameMOV10L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
288 TLKEGRSKTMVIWIE
297 MVIWIENKGDIPQNL

Function

ATP-dependent 5'-3' RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins

Protein Sequence

10 MLSLAAKLVA 20 FFWRTADTPR 30 EEAGQLEPEL 40 AEGDTKLKTV 50 RGVVTRYCSD 60 YGMIDDMIYF 70 SSDAVTSRVL 80 LNVGQEVIAV 90 VEENKVSNGL 100 KAIRVEAVSD 110 KWEDDSRNHG 120 SPSDCGPRVL 130 IGCVTSLVEG 140 AGCISQTTYF 150 SLESVCEGFE 160 PCKGDWVEAE 170 YRIRPGTWSS 180 EATSVKPLRY 190 KRVDKVCISS 200 LCGRNGVLEE 210 SIFFTLDSLK 220 LPDGYTPRRG 230 DVVNAVVVES 240 SQSCYVWRAL 250 CMTLVKRRDA 260 APVHEATHFY 270 GTILLKNKGD 280 IEVTQVTHFG 290 TLKEGRSKTM 300 VIWIENKGDI 310 PQNLVSCKLA 320 GWDKSKQFRF 330 QMLDKDQMCP 340 VVSFVSVPEK 350 ENSSDENINS 360 LNSHTKNKTS 370 QMSESSLVNN 380 RGISPGDCTC 390 KGENGEKDNI 400 LSRKQMTEPE 410 PGGLVPPGGK 420 TFIVVICDGK 430 NPGRCKELLL 440 LCFSDFLIGR 450 YLEVNVISGE 460 ESLIAAREPF 470 SWKKLKSSQA 480 LTSAKTTVVV 490 TAQKRNSRRQ 500 LPSFLPQYPI 510 PDRLRKCVEQ 520 KIDILTFQPL 530 LAELLNMSNY 540 KEKFSTLLWL 550 EEIYAEMELK 560 EYNMSGIILR 570 RNGDLLVLEV 580 PGLAEGRPSL 590 YAGDKLILKT 600 QEYNGHAIEY 610 ISYVTEIHEE 620 DVTLKINPEF 630 EQAYNFEPMD 640 VEFTYNRTTS 650 RRCHFALEHV 660 IHLGVKVLFP 670 EEIILQSPQV 680 TGNWNHAQDT 690 KSSGQSTSKK 700 NRKTMTDQAE 710 HGTEERRVGD 720 KDLPVLAPFT 730 AEMSDWVDEI 740 QTPKARKMEF 750 FNPVLNENQK 760 LAVKRILSGD 770 CRPLPYILFG 780 PPGTGKTVTI 790 IEAVLQVHFA 800 LPDSRILVCA 810 PSNSAADLVC 820 LRLHESKVLQ 830 PATMVRVNAT 840 CRFEEIVIDA 850 VKPYCRDGED 860 IWKASRFRII 870 ITTCSSSGLF 880 YQIGVRVGHF 890 THVFVDEAGQ 900 ASEPECLIPL 910 GLMSDISGQI 920 VLAGDPMQLG 930 PVIKSRLAMA 940 YGLNVSFLER 950 LMSRPAYQRD 960 ENAFGACGAH 970 NPLLVTKLVK 980 NYRSHEALLM 990 LPSRLFYHRE 1000 LEVCADPTVV 1010 TSLLGWEKLP 1020 KKGFPLIFHG 1030 VRGSEAREGK 1040 SPSWFNPAEA 1050 VQVLRYCCLL 1060 AHSISSQVSA 1070 SDIGVITPYR 1080 KQVEKIRILL 1090 RNVDLMDIKV 1100 GSVEEFQGQE 1110 YLVIIISTVR 1120 SNEDRFEDDR 1130 YFLGFLSNSK 1140 RFNVAITRPK 1150 ALLIVLGNPH 1160 VLVRDPCFGA 1170 LLEYSITNGV 1180 YMGCDLPPAL 1190 QSLQNCGEGV 1200 ADPSYPVVPE 1210 STGPEKHQEP S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0007281 germ cell development
Biological Process GO:0007141 male meiosis I
Biological Process GO:0034587 piRNA processing
Biological Process GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0141196 transposable element silencing by piRNA-mediated DNA methylation
Cellular Component GO:0043186 P granule
Cellular Component GO:0071546 pi-body

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.