Overview
| Uniprot ID | Q9BY11 |
|---|
| Protein Name | Protein kinase C and casein kinase substrate in neurons protein 1 |
|---|
| Gene Name | PACSIN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 102 |
SELHQEVKNNLLNED |
| 211 |
KTQEKYEKVLEDVGK |
| 253 |
KEVLLDIKRHLNLAE |
| 322 |
KKEKQPKKAEGVALT |
| 54 |
QERAKIEKAYGQQLT |
| 73 |
RWRQLIEKGPQYGSL |
Function
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation
Protein Sequence
10
MSSSYDEASL
20
APEETTDSFW
30
EVGNYKRTVK
40
RIDDGHRLCN
50
DLMNCVQERA
60
KIEKAYGQQL
70
TDWAKRWRQL
80
IEKGPQYGSL
90
ERAWGAIMTE
100
ADKVSELHQE
110
VKNNLLNEDL
120
EKVKNWQKDA
130
YHKQIMGGFK
140
ETKEAEDGFR
150
KAQKPWAKKM
160
KELEAAKKAY
170
HLACKEEKLA
180
MTREMNSKTE
190
QSVTPEQQKK
200
LQDKVDKCKQ
210
DVQKTQEKYE
220
KVLEDVGKTT
230
PQYMENMEQV
240
FEQCQQFEEK
250
RLVFLKEVLL
260
DIKRHLNLAE
270
NSSYIHVYRE
280
LEQAIRGADA
290
QEDLRWFRST
300
SGPGMPMNWP
310
QFEEWNPDLP
320
HTTTKKEKQP
330
KKAEGVALTN
340
ATGAVESTSQ
350
AGDRGSVSSY
360
DRGQPYATEW
370
SDDESGNPFG
380
GSETNGGANP
390
FEDDSKGVRV
400
RALYDYDGQE
410
QDELSFKAGD
420
ELTKLGEEDE
430
QGWCRGRLDS
440
GQLGLYPANY
VEAI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043679 |
axon terminus |
| Biological Process |
GO:1900006 |
positive regulation of dendrite development |
| Biological Process |
GO:0072657 |
protein localization to membrane |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0030100 |
regulation of endocytosis |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
| Cellular Component |
GO:0030137 |
COPI-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0098684 |
photoreceptor ribbon synapse |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098833 |
presynaptic endocytic zone |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005543 |
phospholipid binding |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0007010 |
cytoskeleton organization |
| Biological Process |
GO:0048812 |
neuron projection morphogenesis |
| Biological Process |
GO:0097320 |
plasma membrane tubulation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.