Search Results

Overview

Uniprot IDQ9BY32
Protein NameInosine triphosphate pyrophosphatase
Gene NameITPA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
172 AEMPKAEKNAVSHRF
9 AASLVGKKIVFVTGN

Function

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions

Protein Sequence

10 MAASLVGKKI 20 VFVTGNAKKL 30 EEVVQILGDK 40 FPCTLVAQKI 50 DLPEYQGEPD 60 EISIQKCQEA 70 VRQVQGPVLV 80 EDTCLCFNAL 90 GGLPGPYIKW 100 FLEKLKPEGL 110 HQLLAGFEDK 120 SAYALCTFAL 130 STGDPSQPVR 140 LFRGRTSGRI 150 VAPRGCQDFG 160 WDPCFQPDGY 170 EQTYAEMPKA 180 EKNAVSHRFR 190 ALLELQEYFG SLAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0035870 dITP diphosphatase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0036220 ITP diphosphatase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0047429 nucleoside triphosphate diphosphatase activity
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0036222 XTP diphosphatase activity
Biological Process GO:0009204 deoxyribonucleoside triphosphate catabolic process
Biological Process GO:0009143 nucleoside triphosphate catabolic process
Biological Process GO:0009117 nucleotide metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.