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Overview

Uniprot IDQ9BY42
Protein NameReplication termination factor 2
Gene NameRTF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 CDGGTIPKRHELVKG
16 PKRHELVKGPKKVEK
203 EKKTKKPKAAESVSK
222 EEAPGPSKVKTGKPE
224 APGPSKVKTGKPEEA
245 KKTNLAPKSTAMNES
256 MNESSSGKAGKPPCG

Function

Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612)

Protein Sequence

10 MGCDGGTIPK 20 RHELVKGPKK 30 VEKVDKDAEL 40 VAQWNYCTLS 50 QEILRRPIVA 60 CELGRLYNKD 70 AVIEFLLDKS 80 AEKALGKAAS 90 HIKSIKNVTE 100 LKLSDNPAWE 110 GDKGNTKGDK 120 HDDLQRARFI 130 CPVVGLEMNG 140 RHRFCFLRCC 150 GCVFSERALK 160 EIKAEVCHTC 170 GAAFQEDDVI 180 MLNGTKEDVD 190 VLKTRMEERR 200 LRAKLEKKTK 210 KPKAAESVSK 220 PDVSEEAPGP 230 SKVKTGKPEE 240 ASLDSREKKT 250 NLAPKSTAMN 260 ESSSGKAGKP 270 PCGATKRSIA 280 DSEESEAYKS 290 LFTTHSSAKR 300 SKEESAHWVT HTSYCF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005657 replication fork
Molecular Function GO:0003677 DNA binding
Biological Process GO:0072711 cellular response to hydroxyurea
Biological Process GO:0097752 regulation of DNA stability

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.