Search Results

Overview

Uniprot ID	Q9BY44
Protein Name	Eukaryotic translation initiation factor 2A
Gene Name	EIF2A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
192	AVYVPGSKGAPSFVR
482	GNDKPLSKTALKNQR
486	PLSKTALKNQRKHEA
505	KQEARSDKSPDLAPT

Function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner

Protein Sequence

10 MAPSTPLLTV 20 RGSEGLYMVN 30 GPPHFTESTV 40 FPRESGKNCK 50 VCIFSKDGTL 60 FAWGNGEKVN 70 IISVTNKGLL 80 HSFDLLKAVC 90 LEFSPKNTVL 100 ATWQPYTTSK 110 DGTAGIPNLQ 120 LYDVKTGTCL 130 KSFIQKKMQN 140 WCPSWSEDET 150 LCARNVNNEV 160 HFFENNNFNT 170 IANKLHLQKI 180 NDFVLSPGPQ 190 PYKVAVYVPG 200 SKGAPSFVRL 210 YQYPNFAGPH 220 AALANKSFFK 230 ADKVTMLWNK 240 KATAVLVIAS 250 TDVDKTGASY 260 YGEQTLHYIA 270 TNGESAVVQL 280 PKNGPIYDVV 290 WNSSSTEFCA 300 VYGFMPAKAT 310 IFNLKCDPVF 320 DFGTGPRNAA 330 YYSPHGHILV 340 LAGFGNLRGQ 350 MEVWDVKNYK 360 LISKPVASDS 370 TYFAWCPDGE 380 HILTATCAPR 390 LRVNNGYKIW 400 HYTGSILHKY 410 DVPSNAELWQ 420 VSWQPFLDGI 430 FPAKTITYQA 440 VPSEVPNEEP 450 KVATAYRPPA 460 LRNKPITNSK 470 LHEEEPPQNM 480 KPQSGNDKPL 490 SKTALKNQRK 500 HEAKKAAKQE 510 ARSDKSPDLA 520 PTPAPQSTPR 530 NTVSQSISGD 540 PEIDKKIKNL 550 KKKLKAIEQL 560 KEQAATGKQL 570 EKNQLEKIQK 580 ETALLQELED LELGI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0043022	ribosome binding
Molecular Function	GO:0003743	translation initiation factor activity
Molecular Function	GO:0000049	tRNA binding
Biological Process	GO:0006417	regulation of translation
Biological Process	GO:1990928	response to amino acid starvation
Biological Process	GO:0042255	ribosome assembly
Biological Process	GO:0006413	translational initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.