Search Results
Overview
| Uniprot ID | Q9BY49 |
|---|---|
| Protein Name | Peroxisomal trans-2-enoyl-CoA reductase |
| Gene Name | PECR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 162 | VNIIVPTKAGFPLAV |
| 282 | PDHDNWPKGAGDLSV |
| 291 | AGDLSVVKKMKETFK |
| 70 | QANLPPTKQARVIPI |
Function
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity
Protein Sequence
10
MASWAKGRSY
20
LAPGLLQGQV
30
AIVTGGATGI
40
GKAIVKELLE
50
LGSNVVIASR
60
KLERLKSAAD
70
ELQANLPPTK
80
QARVIPIQCN
90
IRNEEEVNNL
100
VKSTLDTFGK
110
INFLVNNGGG
120
QFLSPAEHIS
130
SKGWHAVLET
140
NLTGTFYMCK
150
AVYSSWMKEH
160
GGSIVNIIVP
170
TKAGFPLAVH
180
SGAARAGVYN
190
LTKSLALEWA
200
CSGIRINCVA
210
PGVIYSQTAV
220
ENYGSWGQSF
230
FEGSFQKIPA
240
KRIGVPEEVS
250
SVVCFLLSPA
260
ASFITGQSVD
270
VDGGRSLYTH
280
SYEVPDHDNW
290
PKGAGDLSVV
300
KKMKETFKEK
AKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0033306 | phytol metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.