Search Results

Overview

Uniprot IDQ9BY77
Protein NamePolymerase delta-interacting protein 3
Gene NamePOLDIP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
147 TPALKLTKTIQVPQQ
178 VVNNHQAKQNLYDLD
223 SSKLSMSKALPLTKV
248 LPSSIRTKALTNMSR
404 TILKALFKSSGASVT
81 AREKLLQKDARFRIK

Function

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex

Protein Sequence

10 MADISLDELI 20 RKRGAAAKGR 30 LNARPGVGGV 40 RSRVGIQQGL 50 LSQSTRTATF 60 QQRFDARQKI 70 GLSDARLKLG 80 VKDAREKLLQ 90 KDARFRIKGK 100 VQDAREMLNS 110 RKQQTTVPQK 120 PRQVADAREK 130 ISLKRSSPAA 140 FINPPIGTVT 150 PALKLTKTIQ 160 VPQQKAMAPL 170 HPHPAGMRIN 180 VVNNHQAKQN 190 LYDLDEDDDG 200 IASVPTKQMK 210 FAASGGFLHH 220 MAGLSSSKLS 230 MSKALPLTKV 240 VQNDAYTAPA 250 LPSSIRTKAL 260 TNMSRTLVNK 270 EEPPKELPAA 280 EPVLSPLEGT 290 KMTVNNLHPR 300 VTEEDIVELF 310 CVCGALKRAR 320 LVHPGVAEVV 330 FVKKDDAITA 340 YKKYNNRCLD 350 GQPMKCNLHM 360 NGNVITSDQP 370 ILLRLSDSPS 380 MKKESELPRR 390 VNSASSSNPP 400 AEVDPDTILK 410 ALFKSSGASV 420 TTQPTEFKIK L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0016973 poly(A)+ mRNA export from nucleus
Biological Process GO:0045727 positive regulation of translation

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.