Search Results

Overview

Uniprot IDQ9BYG3
Protein NameMKI67 FHA domain-interacting nucleolar phosphoprotein
Gene NameNIFK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
158 RNRTLTQKLRMEERF
198 QKTESISKTNRQTST
206 TNRQTSTKGQVLRKK
216 VLRKKKKKVSGTLDT
246 PTFLERRKSQVAELN
37 RKRITQRKKQEQLTP

Function

No function data available.

Protein Sequence

10 MATFSGPAGP 20 ILSLNPQEDV 30 EFQKEVAQVR 40 KRITQRKKQE 50 QLTPGVVYVR 60 HLPNLLDETQ 70 IFSYFSQFGT 80 VTRFRLSRSK 90 RTGNSKGYAF 100 VEFESEDVAK 110 IVAETMNNYL 120 FGERLLECHF 130 MPPEKVHKEL 140 FKDWNIPFKQ 150 PSYPSVKRYN 160 RNRTLTQKLR 170 MEERFKKKER 180 LLRKKLAKKG 190 IDYDFPSLIL 200 QKTESISKTN 210 RQTSTKGQVL 220 RKKKKKVSGT 230 LDTPEKTVDS 240 QGPTPVCTPT 250 FLERRKSQVA 260 ELNDDDKDDE 270 IVFKQPISCV 280 KEEIQETQTP 290 THSRKKRRRS SNQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003723 RNA binding
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0016072 rRNA metabolic process
Biological Process GO:0009303 rRNA transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.