Search Results

Overview

Uniprot ID	Q9BYT8
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
273	MAFNTRCKEENTIIL
664	MNPEVGMKYRNLILK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity)

Protein Sequence

10 MIARCLLAVR 20 SLRRVGGSRI 30 LLRMTLGREV 40 MSPLQAMSSY 50 TVAGRNVLRW 60 DLSPEQIKTR 70 TEELIVQTKQ 80 VYDAVGMLGI 90 EEVTYENCLQ 100 ALADVEVKYI 110 VERTMLDFPQ 120 HVSSDKEVRA 130 ASTEADKRLS 140 RFDIEMSMRG 150 DIFERIVHLQ 160 ETCDLGKIKP 170 EARRYLEKSI 180 KMGKRNGLHL 190 PEQVQNEIKS 200 MKKRMSELCI 210 DFNKNLNEDD 220 TFLVFSKAEL 230 GALPDDFIDS 240 LEKTDDDKYK 250 ITLKYPHYFP 260 VMKKCCIPET 270 RRRMEMAFNT 280 RCKEENTIIL 290 QQLLPLRTKV 300 AKLLGYSTHA 310 DFVLEMNTAK 320 STSRVTAFLD 330 DLSQKLKPLG 340 EAEREFILNL 350 KKKECKDRGF 360 EYDGKINAWD 370 LYYYMTQTEE 380 LKYSIDQEFL 390 KEYFPIEVVT 400 EGLLNTYQEL 410 LGLSFEQMTD 420 AHVWNKSVTL 430 YTVKDKATGE 440 VLGQFYLDLY 450 PREGKYNHAA 460 CFGLQPGCLL 470 PDGSRMMAVA 480 ALVVNFSQPV 490 AGRPSLLRHD 500 EVRTYFHEFG 510 HVMHQICAQT 520 DFARFSGTNV 530 ETDFVEVPSQ 540 MLENWVWDVD 550 SLRRLSKHYK 560 DGSPIADDLL 570 EKLVASRLVN 580 TGLLTLRQIV 590 LSKVDQSLHT 600 NTSLDAASEY 610 AKYCSEILGV 620 AATPGTNMPA 630 TFGHLAGGYD 640 GQYYGYLWSE 650 VFSMDMFYSC 660 FKKEGIMNPE 670 VGMKYRNLIL 680 KPGGSLDGMD 690 MLHNFLKREP 700 NQKAFLMSRG LHAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Molecular Function	GO:0042277	peptide binding
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0006508	proteolysis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.