Search Results
Overview
| Uniprot ID | Q9BYV7 |
|---|---|
| Protein Name | Carotenoid-cleaving dioxygenase, mitochondrial |
| Gene Name | BCO2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | TETNFMNKVDIETLE |
Function
Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules
Protein Sequence
10
MFFRVFLHFI
20
RSHSATAVDF
30
LPVMVHRLPV
40
FKRYMGNTPQ
50
KKAVFGQCRG
60
LPCVAPLLTT
70
VEEAPRGISA
80
RVWGHFPKWL
90
NGSLLRIGPG
100
KFEFGKDKYN
110
HWFDGMALLH
120
QFRMAKGTVT
130
YRSKFLQSDT
140
YKANSAKNRI
150
VISEFGTLAL
160
PDPCKNVFER
170
FMSRFELPGK
180
AAAMTDNTNV
190
NYVRYKGDYY
200
LCTETNFMNK
210
VDIETLEKTE
220
KVDWSKFIAV
230
NGATAHPHYD
240
LDGTAYNMGN
250
SFGPYGFSYK
260
VIRVPPEKVD
270
LGETIHGVQV
280
ICSIASTEKG
290
KPSYYHSFGM
300
TRNYIIFIEQ
310
PLKMNLWKIA
320
TSKIRGKAFS
330
DGISWEPQCN
340
TRFHVVEKRT
350
GQLLPGRYYS
360
KPFVTFHQIN
370
AFEDQGCVII
380
DLCCQDNGRT
390
LEVYQLQNLR
400
KAGEGLDQVH
410
NSAAKSFPRR
420
FVLPLNVSLN
430
APEGDNLSPL
440
SYTSASAVKQ
450
ADGTIWCSHE
460
NLHQEDLEKE
470
GGIEFPQIYY
480
DRFSGKKYHF
490
FYGCGFRHLV
500
GDSLIKVDVV
510
NKTLKVWRED
520
GFYPSEPVFV
530
PAPGTNEEDG
540
GVILSVVITP
550
NQNESNFILV
560
LDAKNFEELG
570
RAEVPVQMPY
GFHGTFIPI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Biological Process | GO:0016121 | carotene catabolic process |
| Biological Process | GO:0016119 | carotene metabolic process |
| Biological Process | GO:0016116 | carotenoid metabolic process |
| Biological Process | GO:0062172 | lutein catabolic process |
| Biological Process | GO:1901176 | lycopene catabolic process |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0042574 | retinal metabolic process |
| Biological Process | GO:0042573 | retinoic acid metabolic process |
| Biological Process | GO:0016124 | xanthophyll catabolic process |
| Biological Process | GO:1901826 | zeaxanthin catabolic process |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0010437 | 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity |
| Molecular Function | GO:0102076 | beta,beta-carotene-9',10'-cleaving oxygenase activity |
| Molecular Function | GO:0003834 | beta-carotene 15,15'-dioxygenase activity |
| Molecular Function | GO:0010436 | carotenoid dioxygenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.