Search Results

Overview

Uniprot IDQ9BZ29
Protein NameDedicator of cytokinesis protein 9
Gene NameDOCK9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1834 EISQRLLKLYSDKFG

Function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation

Protein Sequence

10 MSQPPLLPAS 20 AETRKFTRAL 30 SKPGTAAELR 40 QSVSEVVRGS 50 VLLAKPKLIE 60 PLDYENVIVQ 70 KKTQILNDCL 80 REMLLFPYDD 90 FQTAILRRQG 100 RYICSTVPAK 110 AEEEAQSLFV 120 TECIKTYNSD 130 WHLVNYKYED 140 YSGEFRQLPN 150 KVVKLDKLPV 160 HVYEVDEEVD 170 KDEDAASLGS 180 QKGGITKHGW 190 LYKGNMNSAI 200 SVTMRSFKRR 210 FFHLIQLGDG 220 SYNLNFYKDE 230 KISKEPKGSI 240 FLDSCMGVVQ 250 NNKVRRFAFE 260 LKMQDKSSYL 270 LAADSEVEME 280 EWITILNKIL 290 QLNFEAAMQE 300 KRNGDSHEDD 310 EQSKLEGSGS 320 GLDSYLPELA 330 KSAREAEIKL 340 KSESRVKLFY 350 LDPDAQKLDF 360 SSAEPEVKSF 370 EEKFGKRILV 380 KCNDLSFNLQ 390 CCVAENEEGP 400 TTNVEPFFVT 410 LSLFDIKYNR 420 KISADFHVDL 430 NHFSVRQMLA 440 TTSPALMNGS 450 GQSPSVLKGI 460 LHEAAMQYPK 470 QGIFSVTCPH 480 PDIFLVARIE 490 KVLQGSITHC 500 AEPYMKSSDS 510 SKVAQKVLKN 520 AKQACQRLGQ 530 YRMPFAWAAR 540 TLFKDASGNL 550 DKNARFSAIY 560 RQDSNKLSND 570 DMLKLLADFR 580 KPEKMAKLPV 590 ILGNLDITID 600 NVSSDFPNYV 610 NSSYIPTKQF 620 ETCSKTPITF 630 EVEEFVPCIP 640 KHTQPYTIYT 650 NHLYVYPKYL 660 KYDSQKSFAK 670 ARNIAICIEF 680 KDSDEEDSQP 690 LKCIYGRPGG 700 PVFTRSAFAA 710 VLHHHQNPEF 720 YDEIKIELPT 730 QLHEKHHLLL 740 TFFHVSCDNS 750 SKGSTKKRDV 760 VETQVGYSWL 770 PLLKDGRVVT 780 SEQHIPVSAN 790 LPSGYLGYQE 800 LGMGRHYGPE 810 IKWVDGGKPL 820 LKISTHLVST 830 VYTQDQHLHN 840 FFQYCQKTES 850 GAQALGNELV 860 KYLKSLHAME 870 GHVMIAFLPT 880 ILNQLFRVLT 890 RATQEEVAVN 900 VTRVIIHVVA 910 QCHEEGLESH 920 LRSYVKYAYK 930 AEPYVASEYK 940 TVHEELTKSM 950 TTILKPSADF 960 LTSNKLLKYS 970 WFFFDVLIKS 980 MAQHLIENSK 990 VKLLRNQRFP 1000 ASYHHAVETV 1010 VNMLMPHITQ 1020 KFRDNPEASK 1030 NANHSLAVFI 1040 KRCFTFMDRG 1050 FVFKQINNYI 1060 SCFAPGDPKT 1070 LFEYKFEFLR 1080 VVCNHEHYIP 1090 LNLPMPFGKG 1100 RIQRYQDLQL 1110 DYSLTDEFCR 1120 NHFLVGLLLR 1130 EVGTALQEFR 1140 EVRLIAISVL 1150 KNLLIKHSFD 1160 DRYASRSHQA 1170 RIATLYLPLF 1180 GLLIENVQRI 1190 NVRDVSPFPV 1200 NAGMTVKDES 1210 LALPAVNPLV 1220 TPQKGSTLDN 1230 SLHKDLLGAI 1240 SGIASPYTTS 1250 TPNINSVRNA 1260 DSRGSLISTD 1270 SGNSLPERNS 1280 EKSNSLDKHQ 1290 QSSTLGNSVV 1300 RCDKLDQSEI 1310 KSLLMCFLYI 1320 LKSMSDDALF 1330 TYWNKASTSE 1340 LMDFFTISEV 1350 CLHQFQYMGK 1360 RYIARTGMMH 1370 ARLQQLGSLD 1380 NSLTFNHSYG 1390 HSDADVLHQS 1400 LLEANIATEV 1410 CLTALDTLSL 1420 FTLAFKNQLL 1430 ADHGHNPLMK 1440 KVFDVYLCFL 1450 QKHQSETALK 1460 NVFTALRSLI 1470 YKFPSTFYEG 1480 RADMCAALCY 1490 EILKCCNSKL 1500 SSIRTEASQL 1510 LYFLMRNNFD 1520 YTGKKSFVRT 1530 HLQVIISVSQ 1540 LIADVVGIGG 1550 TRFQQSLSII 1560 NNCANSDRLI 1570 KHTSFSSDVK 1580 DLTKRIRTVL 1590 MATAQMKEHE 1600 NDPEMLVDLQ 1610 YSLAKSYAST 1620 PELRKTWLDS 1630 MARIHVKNGD 1640 LSEAAMCYVH 1650 VTALVAEYLT 1660 RKEAVQWEPP 1670 LLPHSHSACL 1680 RRSRGGVFRQ 1690 GCTAFRVITP 1700 NIDEEASMME 1710 DVGMQDVHFN 1720 EDVLMELLEQ 1730 CADGLWKAER 1740 YELIADIYKL 1750 IIPIYEKRRD 1760 FERLAHLYDT 1770 LHRAYSKVTE 1780 VMHSGRRLLG 1790 TYFRVAFFGQ 1800 AAQYQFTDSE 1810 TDVEGFFEDE 1820 DGKEYIYKEP 1830 KLTPLSEISQ 1840 RLLKLYSDKF 1850 GSENVKMIQD 1860 SGKVNPKDLD 1870 SKYAYIQVTH 1880 VIPFFDEKEL 1890 QERKTEFERS 1900 HNIRRFMFEM 1910 PFTQTGKRQG 1920 GVEEQCKRRT 1930 ILTAIHCFPY 1940 VKKRIPVMYQ 1950 HHTDLNPIEV 1960 AIDEMSKKVA 1970 ELRQLCSSAE 1980 VDMIKLQLKL 1990 QGSVSVQVNA 2000 GPLAYARAFL 2010 DDTNTKRYPD 2020 NKVKLLKEVF 2030 RQFVEACGQA 2040 LAVNERLIKE 2050 DQLEYQEEMK 2060 ANYREMAKEL SEIMHEQLG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0012505 endomembrane system
Cellular Component GO:0016020 membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.