Search Results

Overview

Uniprot ID	Q9BZE4
Protein Name	GTP-binding protein 4
Gene Name	GTPBP4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
29	TLSKTQRKTPTVIHK
352	ETKMKGNKVNEVLNR
36	KTPTVIHKHYQIHRI
485	LEIRQLAKQIREKKK
594	KKAKTMMKNAQKKMN
625	PKHLLSGKRKAGKKD

Function

Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539)

Protein Sequence

10 MAHYNFKKIT 20 VVPSAKDFID 30 LTLSKTQRKT 40 PTVIHKHYQI 50 HRIRHFYMRK 60 VKFTQQNYHD 70 RLSQILTDFP 80 KLDDIHPFYA 90 DLMNILYDKD 100 HYKLALGQIN 110 IAKNLVDNVA 120 KDYVRLMKYG 130 DSLYRCKQLK 140 RAALGRMCTV 150 IKRQKQSLEY 160 LEQVRQHLSR 170 LPTIDPNTRT 180 LLLCGYPNVG 190 KSSFINKVTR 200 ADVDVQPYAF 210 TTKSLFVGHM 220 DYKYLRWQVV 230 DTPGILDHPL 240 EDRNTIEMQA 250 ITALAHLRAA 260 VLYVMDLSEQ 270 CGHGLREQLE 280 LFQNIRPLFI 290 NKPLIVVANK 300 CDVKRIAELS 310 EDDQKIFTDL 320 QSEGFPVIET 330 STLTEEGVIK 340 VKTEACDRLL 350 AHRVETKMKG 360 NKVNEVLNRL 370 HLAIPTRRDD 380 KERPPFIPEG 390 VVARRKRMET 400 EESRKKRERD 410 LELEMGDDYI 420 LDLQKYWDLM 430 NLSEKHDKIP 440 EIWEGHNIAD 450 YIDPAIMKKL 460 EELEKEEELR 470 TAAGEYDSVS 480 ESEDEEMLEI 490 RQLAKQIREK 500 KKLKILESKE 510 KNTQGPRMPR 520 TAKKVQRTVL 530 EKEMRSLGVD 540 MDDKDDAHYA 550 VQARRSRSIT 560 RKRKREDSAP 570 PSSVARSGSC 580 SRTPRDVSGL 590 RDVKMVKKAK 600 TMMKNAQKKM 610 NRLGKKGEAD 620 RHVFDMKPKH 630 LLSGKRKAGK KDRR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:1990275	preribosome binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0022408	negative regulation of cell-cell adhesion
Biological Process	GO:0008156	negative regulation of DNA replication
Biological Process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
Biological Process	GO:0031397	negative regulation of protein ubiquitination
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0042273	ribosomal large subunit biogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.