Search Results
Overview
| Uniprot ID | Q9BZE9 |
|---|---|
| Protein Name | Tether containing UBX domain for GLUT4 |
| Gene Name | ASPSCR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 268 | PLTSSSAKLPKSLSS |
| 271 | SSSAKLPKSLSSPGG |
| 283 | PGGPSKPKKSKSGQD |
| 286 | PSKPKKSKSGQDPQQ |
| 360 | RRRLAQLKSERKRLE |
| 541 | PVKRSLGKVPKWLKL |
Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT
Protein Sequence
10
MAAPAGGGGS
20
AVSVLAPNGR
30
RHTVKVTPST
40
VLLQVLEDTC
50
RRQDFNPCEY
60
DLKFQRSVLD
70
LSLQWRFANL
80
PNNAKLEMVP
90
ASRSREGPEN
100
MVRIALQLDD
110
GSRLQDSFCS
120
GQTLWELLSH
130
FPQIRECLQH
140
PGGATPVCVY
150
TRDEVTGEAA
160
LRGTTLQSLG
170
LTGGSATIRF
180
VMKCYDPVGK
190
TPGSLGSSAS
200
AGQAAASAPL
210
PLESGELSRG
220
DLSRPEDADT
230
SGPCCEHTQE
240
KQSTRAPAAA
250
PFVPFSGGGQ
260
RLGGPPGPTR
270
PLTSSSAKLP
280
KSLSSPGGPS
290
KPKKSKSGQD
300
PQQEQEQERE
310
RDPQQEQERE
320
RPVDREPVDR
330
EPVVCHPDLE
340
ERLQAWPAEL
350
PDEFFELTVD
360
DVRRRLAQLK
370
SERKRLEEAP
380
LVTKAFREAQ
390
IKEKLERYPK
400
VALRVLFPDR
410
YVLQGFFRPS
420
ETVGDLRDFV
430
RSHLGNPELS
440
FYLFITPPKT
450
VLDDHTQTLF
460
QANLFPAALV
470
HLGAEEPAGV
480
YLEPGLLEHA
490
ISPSAADVLV
500
ARYMSRAAGS
510
PSPLPAPDPA
520
PKSEPAAEEG
530
ALVPPEPIPG
540
TAQPVKRSLG
550
KVPKWLKLPA
SKR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0012506 | vesicle membrane |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0031401 | positive regulation of protein modification process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.