Search Results

Overview

Uniprot ID	Q9BZH6
Protein Name	WD repeat-containing protein 11
Gene Name	WDR11
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
214	HSSPAHNKLATATGA

Function

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865)

Protein Sequence

10 MLPYTVNFKV 20 SARTLTGALN 30 AHNKAAVDWG 40 WQGLIAYGCH 50 SLVVVIDSIT 60 AQTLQVLEKH 70 KADVVKVKWA 80 RENYHHNIGS 90 PYCLRLASAD 100 VNGKIIVWDV 110 AAGVAQCEIQ 120 EHAKPIQDVQ 130 WLWNQDASRD 140 LLLAIHPPNY 150 IVLWNADTGT 160 KLWKKSYADN 170 ILSFSFDPFD 180 PSHLTLLTSE 190 GIVFISDFSP 200 SKPPSGPGKK 210 VYISSPHSSP 220 AHNKLATATG 230 AKKALNKVKI 240 LITQEKPSAE 250 FITLNDCLQL 260 AYLPSKRNHM 270 LLLYPREILI 280 LDLEVNQTVG 290 VIAIERTGVP 300 FLQVIPCFQR 310 DGLFCLHENG 320 CITLRVRRSY 330 NNIFTTSNEE 340 PDPDPVQELT 350 YDLRSQCDAI 360 RVTKTVRPFS 370 MVCCPVNENA 380 AALVVSDGRV 390 MIWELKSAVC 400 NRNSRNSSSG 410 VSPLYSPVSF 420 CGIPVGVLQN 430 KLPDLSLDNM 440 IGQSAIAGEE 450 HPRGSILREV 460 HLKFLLTGLL 470 SGLPAPQFAI 480 RMCPPLTTKN 490 IKMYQPLLAV 500 GTSNGSVLVY 510 HLTSGLLHKE 520 LSIHSCEVKG 530 IEWTSLTSFL 540 SFATSTPNNM 550 GLVRNELQLV 560 DLPTGRSIAF 570 RGERGNDESA 580 IEMIKVSHLK 590 QYLAVVFRDK 600 PLELWDVRTC 610 TLLREMSKNF 620 PTITALEWSP 630 SHNLKSLRKK 640 QLATREAMAR 650 QTVVSDTELS 660 IVESSVISLL 670 QEAESKSELS 680 QNISAREHFV 690 FTDIDGQVYH 700 LTVEGNSVKD 710 SARIPPDGSM 720 GSITCIAWKG 730 DTLVLGDMDG 740 NLNFWDLKGR 750 VSRGIPTHRS 760 WVRKIRFAPG 770 KGNQKLIAMY 780 NDGAEVWDTK 790 EVQMVSSLRS 800 GRNVTFRILD 810 VDWCTSDKVI 820 LASDDGCIRV 830 LEMSMKSACF 840 RMDEQELTEP 850 VWCPYLLVPR 860 ASLALKAFLL 870 HQPWNGQYSL 880 DISHVDYPEN 890 EEIKNLLQEQ 900 LNSLSNDIKK 910 LLLDPEFTLL 920 QRCLLVSRLY 930 GDESELHFWT 940 VAAHYLHSLS 950 QEKSASTTAP 960 KEAAPRDKLS 970 NPLDICYDVL 980 CENAYFQKFQ 990 LERVNLQEVK 1000 RSTYDHTRKC 1010 TDQLLLLGQT 1020 DRAVQLLLET 1030 SADNQHYYCD 1040 SLKACLVTTV 1050 TSSGPSQSTI 1060 KLVATNMIAN 1070 GKLAEGVQLL 1080 CLIDKAADAC 1090 RYLQTYGEWN 1100 RAAWLAKVRL 1110 NPEECADVLR 1120 RWVDHLCSPQ 1130 VNQKSKALLV 1140 LLSLGCFFSV 1150 AETLHSMRYF 1160 DRAALFVEAC 1170 LKYGAFEVTE 1180 DTEKLITAIY 1190 ADYARSLKNL 1200 GFKQGAVLFA 1210 SKAGAAGKDL 1220 LNELESPKEE PIEE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005930	axoneme
Cellular Component	GO:0036064	ciliary basal body
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005802	trans-Golgi network
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0060322	head development
Biological Process	GO:0007507	heart development
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0035264	multicellular organism growth
Biological Process	GO:0008589	regulation of smoothened signaling pathway
Biological Process	GO:0099041	vesicle tethering to Golgi

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.