Search Results
Overview
| Uniprot ID | Q9BZI7 |
|---|---|
| Protein Name | Regulator of nonsense transcripts 3B |
| Gene Name | UPF3B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 303 | DKREKAKKLDKENLS |
| 384 | KERYEKEKTFKRKEE |
| 434 | KRDRIRNKDRPAMQL |
| 52 | EKKEALSKVVIRRLP |
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core
Protein Sequence
10
MKEEKEHRPK
20
EKRVTLLTPA
30
GATGSGGGTS
40
GDSSKGEDKQ
50
DRNKEKKEAL
60
SKVVIRRLPP
70
TLTKEQLQEH
80
LQPMPEHDYF
90
EFFSNDTSLY
100
PHMYARAYIN
110
FKNQEDIILF
120
RDRFDGYVFL
130
DNKGQEYPAI
140
VEFAPFQKAA
150
KKKTKKRDTK
160
VGTIDDDPEY
170
RKFLESYATD
180
NEKMTSTPET
190
LLEEIEAKNR
200
ELIAKKTTPL
210
LSFLKNKQRM
220
REEKREERRR
230
REIERKRQRE
240
EERRKWKEEE
250
KRKRKDIEKL
260
KKIDRIPERD
270
KLKDEPKIKV
280
HRFLLQAVNQ
290
KNLLKKPEKG
300
DEKELDKREK
310
AKKLDKENLS
320
DERASGQSCT
330
LPKRSDSELK
340
DEKPKRPEDE
350
SGRDYRERER
360
EYERDQERIL
370
RERERLKRQE
380
EERRRQKERY
390
EKEKTFKRKE
400
EEMKKEKDTL
410
RDKGKKAEST
420
ESIGSSEKTE
430
KKEEVVKRDR
440
IRNKDRPAMQ
450
LYQPGARSRN
460
RLCPPDDSTK
470
SGDSAAERKQ
480
ESGISHRKEG
GEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0035145 | exon-exon junction complex |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| Biological Process | GO:0045727 | positive regulation of translation |
Reference
PMID: N/A