Search Results

Overview

Uniprot IDQ9BZJ0
Protein NameCrooked neck-like protein 1
Gene NameCRNKL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
175 AGKQRIPKVAKVKNK
180 IPKVAKVKNKAPAEV
182 KVAKVKNKAPAEVQI
475 IEDIIVSKRRFQYEE
823 LKLLAMAKLWKKQQQ

Function

Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MTATVENLTF 20 QKDTLGNAVD 30 KNTSRLELRS 40 YSLAGRHGST 50 EPLVLAWSSQ 60 FRRLTWGCAL 70 DALHRSPCVA 80 ASQHGVTHLI 90 RSSRTPHSTR 100 CRKEDAQPGH 110 HGNGAASVTA 120 QARGQRSVLQ 130 VPLPVPRSCL 140 FSESFVVSVS 150 SQSRFLASVP 160 GTGVQRSTAA 170 DMAASTAAGK 180 QRIPKVAKVK 190 NKAPAEVQIT 200 AEQLLREAKE 210 RELELLPPPP 220 QQKITDEEEL 230 NDYKLRKRKT 240 FEDNIRKNRT 250 VISNWIKYAQ 260 WEESLKEIQR 270 ARSIYERALD 280 VDYRNITLWL 290 KYAEMEMKNR 300 QVNHARNIWD 310 RAITTLPRVN 320 QFWYKYTYME 330 EMLGNVAGAR 340 QVFERWMEWQ 350 PEEQAWHSYI 360 NFELRYKEVD 370 RARTIYERFV 380 LVHPDVKNWI 390 KYARFEEKHA 400 YFAHARKVYE 410 RAVEFFGDEH 420 MDEHLYVAFA 430 KFEENQKEFE 440 RVRVIYKYAL 450 DRISKQDAQE 460 LFKNYTIFEK 470 KFGDRRGIED 480 IIVSKRRFQY 490 EEEVKANPHN 500 YDAWFDYLRL 510 VESDAEAEAV 520 REVYERAIAN 530 VPPIQEKRHW 540 KRYIYLWINY 550 ALYEELEAKD 560 PERTRQVYQA 570 SLELIPHKKF 580 TFAKMWILYA 590 QFEIRQKNLS 600 LARRALGTSI 610 GKCPKNKLFK 620 VYIELELQLR 630 EFDRCRKLYE 640 KFLEFGPENC 650 TSWIKFAELE 660 TILGDIDRAR 670 AIYELAISQP 680 RLDMPEVLWK 690 SYIDFEIEQE 700 ETERTRNLYR 710 RLLQRTQHVK 720 VWISFAQFEL 730 SSGKEGSLTK 740 CRQIYEEANK 750 TMRNCEEKEE 760 RLMLLESWRS 770 FEEEFGTASD 780 KERVDKLMPE 790 KVKKRRKVQT 800 DDGSDAGWEE 810 YFDYIFPEDA 820 ANQPNLKLLA 830 MAKLWKKQQQ 840 EKEDAEHHPD EDVDESES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000245 spliceosomal complex assembly
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071014 post-mRNA release spliceosomal complex
Cellular Component GO:0000974 Prp19 complex
Cellular Component GO:0005681 spliceosomal complex

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.