Search Results

Overview

Uniprot ID	Q9BZK7
Protein Name	F-box-like/WD repeat-containing protein TBL1XR1
Gene Name	TBL1XR1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	RQQAYRDKLAQQQAA

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation

Protein Sequence

10 MSISSDEVNF 20 LVYRYLQESG 30 FSHSAFTFGI 40 ESHISQSNIN 50 GALVPPAALI 60 SIIQKGLQYV 70 EAEVSINEDG 80 TLFDGRPIES 90 LSLIDAVMPD 100 VVQTRQQAYR 110 DKLAQQQAAA 120 AAAAAAAASQ 130 QGSAKNGENT 140 ANGEENGAHT 150 IANNHTDMME 160 VDGDVEIPPN 170 KAVVLRGHES 180 EVFICAWNPV 190 SDLLASGSGD 200 STARIWNLSE 210 NSTSGSTQLV 220 LRHCIREGGQ 230 DVPSNKDVTS 240 LDWNSEGTLL 250 ATGSYDGFAR 260 IWTKDGNLAS 270 TLGQHKGPIF 280 ALKWNKKGNF 290 ILSAGVDKTT 300 IIWDAHTGEA 310 KQQFPFHSAP 320 ALDVDWQSNN 330 TFASCSTDMC 340 IHVCKLGQDR 350 PIKTFQGHTN 360 EVNAIKWDPT 370 GNLLASCSDD 380 MTLKIWSMKQ 390 DNCVHDLQAH 400 NKEIYTIKWS 410 PTGPGTNNPN 420 ANLMLASASF 430 DSTVRLWDVD 440 RGICIHTLTK 450 HQEPVYSVAF 460 SPDGRYLASG 470 SFDKCVHIWN 480 TQTGALVHSY 490 RGTGGIFEVC 500 WNAAGDKVGA 510 SASDGSVCVL DLRK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000118	histone deacetylase complex
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0017053	transcription repressor complex
Molecular Function	GO:0008013	beta-catenin binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.