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Overview

Uniprot IDQ9BZV1
Protein NameUBX domain-containing protein 6
Gene NameUBXN6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
15 FKADIKFKSAGPGQK
166 MKIYTFNKDQDRVKL
3 *****MKKFFQEFKA

Function

May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622)

Protein Sequence

10 MKKFFQEFKA 20 DIKFKSAGPG 30 QKLKESVGEK 40 AHKEKPNQPA 50 PRPPRQGPTN 60 EAQMAAAAAL 70 ARLEQKQSRA 80 WGPTSQDTIR 90 NQVRKELQAE 100 ATVSGSPEAP 110 GTNVVSEPRE 120 EGSAHLAVPG 130 VYFTCPLTGA 140 TLRKDQRDAC 150 IKEAILLHFS 160 TDPVAASIMK 170 IYTFNKDQDR 180 VKLGVDTIAK 190 YLDNIHLHPE 200 EEKYRKIKLQ 210 NKVFQERINC 220 LEGTHEFFEA 230 IGFQKVLLPA 240 QDQEDPEEFY 250 VLSETTLAQP 260 QSLERHKEQL 270 LAAEPVRAKL 280 DRQRRVFQPS 290 PLASQFELPG 300 DFFNLTAEEI 310 KREQRLRSEA 320 VERLSVLRTK 330 AMREKEEQRG 340 LRKYNYTLLR 350 VRLPDGCLLQ 360 GTFYARERLG 370 AVYGFVREAL 380 QSDWLPFELL 390 ASGGQKLSED 400 ENLALNECGL 410 VPSALLTFSW 420 DMAVLEDIKA 430 AGAEPDSILK 440 PELLSAIEKL L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0051117 ATPase binding
Biological Process GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0016236 macroautophagy
Biological Process GO:0000423 mitophagy
Biological Process GO:0043335 protein unfolding

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.