Overview
| Uniprot ID | Q9BZX2 |
|---|
| Protein Name | Uridine-cytidine kinase 2 |
|---|
| Gene Name | UCK2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 202 |
EFCLPTKKYADVIIP |
Function
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055, PubMed:35583288). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702)
Protein Sequence
10
MAGDSEQTLQ
20
NHQQPNGGEP
30
FLIGVSGGTA
40
SGKSSVCAKI
50
VQLLGQNEVD
60
YRQKQVVILS
70
QDSFYRVLTS
80
EQKAKALKGQ
90
FNFDHPDAFD
100
NELILKTLKE
110
ITEGKTVQIP
120
VYDFVSHSRK
130
EETVTVYPAD
140
VVLFEGILAF
150
YSQEVRDLFQ
160
MKLFVDTDAD
170
TRLSRRVLRD
180
ISERGRDLEQ
190
ILSQYITFVK
200
PAFEEFCLPT
210
KKYADVIIPR
220
GADNLVAINL
230
IVQHIQDILN
240
GGPSKRQTNG
250
CLNGYTPSRK
260
RQASESSSRP
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0043771 |
cytidine kinase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004849 |
uridine kinase activity |
| Biological Process |
GO:0071453 |
cellular response to oxygen levels |
| Biological Process |
GO:0044211 |
CTP salvage |
| Biological Process |
GO:0007631 |
feeding behavior |
| Biological Process |
GO:0048678 |
response to axon injury |
| Biological Process |
GO:0044206 |
UMP salvage |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.