Search Results

Overview

Uniprot ID	Q9C005
Protein Name	Protein dpy-30 homolog
Gene Name	DPY30
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
35	ERIVENEKINAEKSS
43	INAEKSSKQKVDLQS
45	AEKSSKQKVDLQSLP

Function

As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport

Protein Sequence

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0035097	histone methyltransferase complex
Cellular Component	GO:0044666	MLL3/4 complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048188	Set1C/COMPASS complex
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0016197	endosomal transport
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.