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Overview

Uniprot ID	Q9C040
Protein Name	Tripartite motif-containing protein 2
Gene Name	TRIM2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
464	MYSTGKRKENPIEDD

Function

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738)

Protein Sequence

10 MASEGTNIPS 20 PVVRQIDKQF 30 LICSICLERY 40 KNPKVLPCLH 50 TFCERCLQNY 60 IPAHSLTLSC 70 PVCRQTSILP 80 EKGVAALQNN 90 FFITNLMDVL 100 QRTPGSNAEE 110 SSILETVTAV 120 AAGKPLSCPN 130 HDGNVMEFYC 140 QSCETAMCRE 150 CTEGEHAEHP 160 TVPLKDVVEQ 170 HKASLQVQLD 180 AVNKRLPEID 190 SALQFISEII 200 HQLTNQKASI 210 VDDIHSTFDE 220 LQKTLNVRKS 230 VLLMELEVNY 240 GLKHKVLQSQ 250 LDTLLQGQES 260 IKSCSNFTAQ 270 ALNHGTETEV 280 LLVKKQMSEK 290 LNELADQDFP 300 LHPRENDQLD 310 FIVETEGLKK 320 SIHNLGTILT 330 TNAVASETVA 340 TGEGLRQTII 350 GQPMSVTITT 360 KDKDGELCKT 370 GNAYLTAELS 380 TPDGSVADGE 390 ILDNKNGTYE 400 FLYTVQKEGD 410 FTLSLRLYDQ 420 HIRGSPFKLK 430 VIRSADVSPT 440 TEGVKRRVKS 450 PGSGHVKQKA 460 VKRPASMYST 470 GKRKENPIED 480 DLIFRVGTKG 490 RNKGEFTNLQ 500 GVAASTNGKI 510 LIADSNNQCV 520 QIFSNDGQFK 530 SRFGIRGRSP 540 GQLQRPTGVA 550 VHPSGDIIIA 560 DYDNKWVSIF 570 SSDGKFKTKI 580 GSGKLMGPKG 590 VSVDRNGHII 600 VVDNKACCVF 610 IFQPNGKIVT 620 RFGSRGNGDR 630 QFAGPHFAAV 640 NSNNEIIITD 650 FHNHSVKVFN 660 QEGEFMLKFG 670 SNGEGNGQFN 680 APTGVAVDSN 690 GNIIVADWGN 700 SRIQVFDGSG 710 SFLSYINTSA 720 DPLYGPQGLA 730 LTSDGHVVVA 740 DSGNHCFKVY RYLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0004842	ubiquitin-protein transferase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0043523	regulation of neuron apoptotic process

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.