Search Results

Overview

Uniprot ID	Q9C0A6
Protein Name	Histone-lysine N-methyltransferase SETD5
Gene Name	SETD5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1095	DSAQSKSKSAGAGQG
415	NRNCPIQKRNPNATE
514	RRTREDRKVEAIMHA

Function

Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion

Protein Sequence

10 MSIAIPLGVT 20 TSDTSYSDMA 30 AGSDPESVEA 40 SPAVNEKSVY 50 STHNYGTTQR 60 HGCRGLPYAT 70 IIPRSDLNGL 80 PSPVEERCGD 90 SPNSEGETVP 100 TWCPCGLSQD 110 GFLLNCDKCR 120 GMSRGKVIRL 130 HRRKQDNISG 140 GDSSATESWD 150 EELSPSTVLY 160 TATQHTPTSI 170 TLTVRRTKPK 180 KRKKSPEKGR 190 AAPKTKKIKN 200 SPSEAQNLDE 210 NTTEGWENRI 220 RLWTDQYEEA 230 FTNQYSADVQ 240 NALEQHLHSS 250 KEFVGKPTIL 260 DTINKTELAC 270 NNTVIGSQMQ 280 LQLGRVTRVQ 290 KHRKILRAAR 300 DLALDTLIIE 310 YRGKVMLRQQ 320 FEVNGHFFKK 330 PYPFVLFYSK 340 FNGVEMCVDA 350 RTFGNDARFI 360 RRSCTPNAEV 370 RHMIADGMIH 380 LCIYAVSAIT 390 KDAEVTIAFD 400 YEYSNCNYKV 410 DCACHKGNRN 420 CPIQKRNPNA 430 TELPLLPPPP 440 SLPTIGAETR 450 RRKARRKELE 460 MEQQNEASEE 470 NNDQQSQEVP 480 EKVTVSSDHE 490 EVDNPEEKPE 500 EEKEEVIDDQ 510 ENLAHSRRTR 520 EDRKVEAIMH 530 AFENLEKRKK 540 RRDQPLEQSN 550 SDVEITTTTS 560 ETPVGEETKT 570 EAPESEVSNS 580 VSNVTIPSTP 590 QSVGVNTRRS 600 SQAGDIAAEK 610 LVPKPPPAKP 620 SRPRPKSRIS 630 RYRTSSAQRL 640 KRQKQANAQQ 650 AELSQAALEE 660 GGSNSLVTPT 670 EAGSLDSSGE 680 NRPLTGSDPT 690 VVSITGSHVN 700 RAASKYPKTK 710 KYLVTEWLND 720 KAEKQECPVE 730 CPLRITTDPT 740 VLATTLNMLP 750 GLIHSPLICT 760 TPKHYIRFGS 770 PFIPERRRRP 780 LLPDGTFSSC 790 KKRWIKQALE 800 EGMTQTSSVP 810 QETRTQHLYQ 820 SNENSSSSSI 830 CKDNADLLSP 840 LKKWKSRYLM 850 EQNVTKLLRP 860 LSPVTPPPPN 870 SGSKSPQLAT 880 PGSSHPGEEE 890 CRNGYSLMFS 900 PVTSLTTASR 910 CNTPLQFELC 920 HRKDLDLAKV 930 GYLDSNTNSC 940 ADRPSLLNSG 950 HSDLAPHPSL 960 GPTSETGFPS 970 RSGDGHQTLV 980 RNSDQAFRTE 990 FNLMYAYSPL 1000 NAMPRADGLY 1010 RGSPLVGDRK 1020 PLHLDGGYCS 1030 PAEGFSSRYE 1040 HGLMKDLSRG 1050 SLSPGGERAC 1060 EGVPSAPQNP 1070 PQRKKVSLLE 1080 YRKRKQEAKE 1090 NSAGGGGDSA 1100 QSKSKSAGAG 1110 QGSSNSVSDT 1120 GAHGVQGSSA 1130 RTPSSPHKKF 1140 SPSHSSMSHL 1150 EAVSPSDSRG 1160 TSSSHCRPQE 1170 NISSRWMVPT 1180 SVERLREGGS 1190 IPKVLRSSVR 1200 VAQKGEPSPT 1210 WESNITEKDS 1220 DPADGEGPET 1230 LSSALSKGAT 1240 VYSPSRYSYQ 1250 LLQCDSPRTE 1260 SQSLLQQSSS 1270 PFRGHPTQSP 1280 GYSYRTTALR 1290 PGNPPSHGSS 1300 ESSLSSTSYS 1310 SPAHPVSTDS 1320 LAPFTGTPGY 1330 FSSQPHSGNS 1340 TGSNLPRRSC 1350 PSSAASPTLQ 1360 GPSDSPTSDS 1370 VSQSSTGTLS 1380 STSFPQNSRS 1390 SLPSDLRTIS 1400 LPSAGQSAVY 1410 QASRVSAVSN 1420 SQHYPHRGSG 1430 GVHQYRLQPL 1440 QGSGVKTQTG LS

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0050890	cognition
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0070210	Rpd3L-Expanded complex
Cellular Component	GO:0034967	Set3 complex
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity
Molecular Function	GO:0140955	histone H3K36 trimethyltransferase activity
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity
Molecular Function	GO:0140948	histone H3K9 monomethyltransferase activity
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0032259	methylation
Biological Process	GO:0016480	negative regulation of transcription by RNA polymerase III
Biological Process	GO:1902275	regulation of chromatin organization
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0032784	regulation of DNA-templated transcription elongation
Biological Process	GO:0051963	regulation of synapse assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.