Search Results
Overview
| Uniprot ID | Q9C0B0 |
|---|---|
| Protein Name | RING finger protein unkempt homolog |
| Gene Name | UNK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 437 | KNFKCQAKLKPHSLE |
Function
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280)
Protein Sequence
10
MSKGPGPGGS
20
AASSAPPAAT
30
AQVLQAQPEK
40
PQHYTYLKEF
50
RTEQCPLFVQ
60
HKCTQHRPYT
70
CFHWHFVNQR
80
RRRSIRRRDG
90
TFNYSPDVYC
100
TKYDEATGLC
110
PEGDECPFLH
120
RTTGDTERRY
130
HLRYYKTGIC
140
IHETDSKGNC
150
TKNGLHCAFA
160
HGPHDLRSPV
170
YDIRELQAME
180
ALQNGQTTVE
190
GSIEGQSAGA
200
ASHAMIEKIL
210
SEEPRWQETA
220
YVLGNYKTEP
230
CKKPPRLCRQ
240
GYACPYYHNS
250
KDRRRSPRKH
260
KYRSSPCPNV
270
KHGDEWGDPG
280
KCENGDACQY
290
CHTRTEQQFH
300
PEIYKSTKCN
310
DMQQSGSCPR
320
GPFCAFAHVE
330
QPPLSDDLQP
340
SSAVSSPTQP
350
GPVLYMPSAA
360
GDSVPVSPSS
370
PHAPDLSALL
380
CRNSSLGSPS
390
NLCGSPPGSI
400
RKPPNLEGIV
410
FPGESGLAPG
420
SYKKAPGFER
430
EDQVGAEYLK
440
NFKCQAKLKP
450
HSLEPRSQEQ
460
PLLQPKQDML
470
GILPAGSPLT
480
SSISSSITSS
490
LAATPPSPVG
500
TSSVPGMNAN
510
ALPFYPTSDT
520
VESVIESALD
530
DLDLNEFGVA
540
ALEKTFDNST
550
VPHPGSITIG
560
GSLLQSSAPV
570
NIPGSLGSSA
580
SFHSASPSPP
590
VSLSSHFLQQ
600
PQGHLSQSEN
610
TFLGTSASHG
620
SLGLNGMNSS
630
IWEHFASGSF
640
SPGTSPAFLS
650
GPGAAELARL
660
RQELDEANST
670
IKQWEESWKQ
680
AKQACDAWKK
690
EAEEAGERAS
700
AAGAECELAR
710
EQRDALEVQV
720
KKLQEELERL
730
HAGPEPQALP
740
AFSDLEALSL
750
STLYSLQKQL
760
RAHLEQVDKA
770
VFHMQSVKCL
780
KCQEQKRAVL
790
PCQHAALCEL
800
CAEGSECPIC
810
QPGRAHTLQS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:1990715 | mRNA CDS binding |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0048667 | cell morphogenesis involved in neuron differentiation |
| Biological Process | GO:2000766 | negative regulation of cytoplasmic translation |
Reference
PMID: N/A