Search Results

Overview

Uniprot ID	Q9C0C2
Protein Name	182 kDa tankyrase-1-binding protein
Gene Name	TNKS1BP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1236	SDVNVKSKDLAEVGE
1641	TRMSLGTKGLKVNLF
1657	GLSPSALKAKLRPRN
1676	EGELAESKSSQKESA
1691	VQRSKSCKVPGLGKP
777	GERDWTSKYGQGAGE
827	AQDRVVGKPAQLGTQ
954	PQEQEFGKSAWIRDY

Function

No function data available.

Protein Sequence

10 MKVSTLRESS 20 AMASPLPREM 30 EEELVPTGSE 40 PGDTRAKPPV 50 KPKPRALPAK 60 PALPAKPSLL 70 VPVGPRPPRG 80 PLAELPSARK 90 MNMLAGPQPY 100 GGSKRPLPFA 110 PRPAVEASTG 120 GEATQETGKE 130 EAGKEEPPPL 140 TPPARCAAPG 150 GVRKAPAPFR 160 PASERFAATT 170 VEEILAKMEQ 180 PRKEVLASPD 190 RLWGSRLTFN 200 HDGSSRYGPR 210 TYGTTTAPRD 220 EDGSTLFRGW 230 SQEGPVKSPA 240 ECREEHSKTP 250 EERSLPSDLA 260 FNGDLAKAAS 270 SELPADISKP 280 WIPSSPAPSS 290 ENGGPASPGL 300 PAEASGSGPG 310 SPHLHPPDKS 320 SPCHSQLLEA 330 QTPEASQASP 340 CPAVTPSAPS 350 AALPDEGSRH 360 TPSPGLPAEG 370 APEAPRPSSP 380 PPEVLEPHSL 390 DQPPATSPRP 400 LIEVGELLDL 410 TRTFPSGGEE 420 EAKGDAHLRP 430 TSLVQRRFSE 440 GVLQSPSQDQ 450 EKLGGSLAAL 460 PQGQGSQLAL 470 DRPFGAESNW 480 SLSQSFEWTF 490 PTRPSGLGVW 500 RLDSPPPSPI 510 TEASEAAEAA 520 EAGNLAVSSR 530 EEGVSQQGQG 540 AGSAPSGSGS 550 SWVQGDDPSM 560 SLTQKGDGES 570 QPQFPAVPLE 580 PLPTTEGTPG 590 LPLQQAEERY 600 ESQEPLAGQE 610 SPLPLATREA 620 ALPILEPVLG 630 QEQPAAPDQP 640 CVLFADAPEP 650 GQALPVEEEA 660 VTLARAETTQ 670 ARTEAQDLCR 680 ASPEPPGPES 690 SSRWLDDLLA 700 SPPPSGGGAR 710 RGAGAELKDT 720 QSPSTCSEGL 730 LGWSQKDLQS 740 EFGITGDPQP 750 SSFSPSSWCQ 760 GASQDYGLGG 770 ASPRGDPGLG 780 ERDWTSKYGQ 790 GAGEGSTREW 800 ASRCGIGQEE 810 MEASSSQDQS 820 KVSAPGVLTA 830 QDRVVGKPAQ 840 LGTQRSQEAD 850 VQDWEFRKRD 860 SQGTYSSRDA 870 ELQDQEFGKR 880 DSLGTYSSRD 890 VSLGDWEFGK 900 RDSLGAYASQ 910 DANEQGQDLG 920 KRDHHGRYSS 930 QDADEQDWEF 940 QKRDVSLGTY 950 GSRAAEPQEQ 960 EFGKSAWIRD 970 YSSGGSSRTL 980 DAQDRSFGTR 990 PLSSGFSPEE 1000 AQQQDEEFEK 1010 KIPSVEDSLG 1020 EGSRDAGRPG 1030 ERGSGGLFSP 1040 STAHVPDGAL 1050 GQRDQSSWQN 1060 SDASQEVGGH 1070 QERQQAGAQG 1080 PGSADLEDGE 1090 MGKRGWVGEF 1100 SLSVGPQREA 1110 AFSPGQQDWS 1120 RDFCIEASER 1130 SYQFGIIGND 1140 RVSGAGFSPS 1150 SKMEGGHFVP 1160 PGKTTAGSVD 1170 WTDQLGLRNL 1180 EVSSCVGSGG 1190 SSEARESAVG 1200 QMGWSGGLSL 1210 RDMNLTGCLE 1220 SGGSEEPGGI 1230 GVGEKDWTSD 1240 VNVKSKDLAE 1250 VGEGGGHSQA 1260 RESGVGQTDW 1270 SGVEAGEFLK 1280 SRERGVGQAD 1290 WTPDLGLRNM 1300 APGAVCSPGE 1310 SKELGVGQMD 1320 WGNNLGLRDL 1330 EVTCDPDSGG 1340 SQGLRGCGVG 1350 QMDWTQDLAP 1360 QNVELFGAPS 1370 EAREHGVGGV 1380 SQCPEPGLRH 1390 NGSLSPGLEA 1400 RDPLEARELG 1410 VGETSGPETQ 1420 GEDYSSSSLE 1430 PHPADPGMET 1440 GEALSFGASP 1450 GRCPARPPPS 1460 GSQGLLEEML 1470 AASSSKAVAR 1480 RESAASGLGG 1490 LLEEEGAGAG 1500 AAQEEVLEPG 1510 RDSPPSWRPQ 1520 PDGEASQTED 1530 VDGTWGSSAA 1540 RWSDQGPAQT 1550 SRRPSQGPPA 1560 RSPSQDFSFI 1570 EDTEILDSAM 1580 YRSRANLGRK 1590 RGHRAPVIRP 1600 GGTLGLSEAA 1610 DSDAHLFQDS 1620 TEPRASRVPS 1630 SDEEVVEEPQ 1640 SRRTRMSLGT 1650 KGLKVNLFPG 1660 LSPSALKAKL 1670 RPRNRSAEEG 1680 ELAESKSSQK 1690 ESAVQRSKSC 1700 KVPGLGKPLT 1710 LPPKPEKSSG 1720 SEGSSPNWLQ ALKLKKKKV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0030014	CCR4-NOT complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000792	heterochromatin
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0071532	ankyrin repeat binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity
Molecular Function	GO:0044877	protein-containing complex binding
Biological Process	GO:0071479	cellular response to ionizing radiation
Biological Process	GO:0006302	double-strand break repair
Biological Process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
Biological Process	GO:0007004	telomere maintenance via telomerase

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.