Search Results
Overview
| Uniprot ID | Q9C0D0 |
|---|---|
| Protein Name | Phosphatase and actin regulator 1 |
| Gene Name | PHACTR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 550 | TRLTAADKAAIRKEL |
Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity)
Protein Sequence
10
MDYPKMDYFL
20
DVESAHRLLD
30
VESAQRFFYS
40
QGAQARRATL
50
LLPPTLMAAS
60
SEDDIDRRPI
70
RRVRSKSDTP
80
YLAEARISFN
90
LGAAEEVERL
100
AAMRSDSLVP
110
GTHTPPIRRR
120
SKFANLGRIF
130
KPWKWRKKKS
140
EKFKHTSAAL
150
ERKISMRQSR
160
EELIKRGVLK
170
EIYDKDGELS
180
ISNEEDSLEN
190
GQSLSSSQLS
200
LPALSEMEPV
210
PMPRDPCSYE
220
VLQPSDIMDG
230
PDPGAPVKLP
240
CLPVKLSPPL
250
PPKKVMICMP
260
VGGPDLSLVS
270
YTAQKSGQQG
280
VAQHHHTVLP
290
SQIQHQLQYG
300
SHGQHLPSTT
310
GSLPMHPSGC
320
RMIDELNKTL
330
AMTMQRLESS
340
EQRVPCSTSY
350
HSSGLHSGDG
360
VTKAGPMGLP
370
EIRQVPTVVI
380
ECDDNKENVP
390
HESDYEDSSC
400
LYTREEEEEE
410
EDEDDDSSLY
420
TSSLAMKVCR
430
KDSLAIKLSN
440
RPSKRELEEK
450
NILPRQTDEE
460
RLELRQQIGT
470
KLTRRLSQRP
480
TAEELEQRNI
490
LKPRNEQEEQ
500
EEKREIKRRL
510
TRKLSQRPTV
520
EELRERKILI
530
RFSDYVEVAD
540
AQDYDRRADK
550
PWTRLTAADK
560
AAIRKELNEF
570
KSTEMEVHEL
580
SRHLTRFHRP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0140059 | dendrite arborization |
| Biological Process | GO:2001222 | regulation of neuron migration |
| Biological Process | GO:0043149 | stress fiber assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.