Search Results

Overview

Uniprot ID	Q9C0D6
Protein Name	FH2 domain-containing protein 1
Gene Name	FHDC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
987	SFKKPSAKPLRNLPR

Function

Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020)

Protein Sequence

10 MHVMNCVSLV 20 SDKENGNIAT 30 APGFMIGQTP 40 PPAPPPPPPP 50 PPPSPPCSCS 60 REECPSSPPP 70 PPPPPLPGEP 80 PIPPPPPGLP 90 PTTHMNGYSH 100 LGKKKRMRSF 110 FWKTIPEEQV 120 RGKTNIWTLA 130 ARQEHHYQID 140 TKTIEELFGQ 150 QEDTTKSSLP 160 RRGRTLNSSF 170 REAREEITIL 180 DAKRSMNIGI 190 FLKQFKKSPR 200 SIVEDIHQGK 210 SEHYGSETLR 220 EFLKFLPESE 230 EVKKLKAFSG 240 DVSKLSLADS 250 FLYGLIQVPN 260 YSLRIEAMVL 270 KKEFLPSCSS 280 LYTDITVLRT 290 AIKELMSCEE 300 LHSILHLVLQ 310 AGNIMNAGGY 320 AGNAVGFKLS 330 SLLKLADTKA 340 NKPGMNLLHF 350 VAQEAQKKDT 360 ILLNFSEKLH 370 HVQKTARLSL 380 ENTEAELHLL 390 FVRTKSLKEN 400 IQRDGELCQQ 410 MEDFLQFAIE 420 KLRELECWKQ 430 ELQDEAYTLI 440 DFFCEDKKTM 450 KLDECFQIFR 460 DFCTKFNKAV 470 KDNHDREAQE 480 LRQLQRLKEQ 490 EQKQRSWATG 500 ELGAFGRSSS 510 ENDVELLTKK 520 GAEGLLPFLH 530 PRPISPSSPS 540 YRPPNTRRSR 550 LSLGPSADRE 560 LLTFLESSTG 570 SPEEPNKFHS 580 LPRSSPRQAR 590 PTIACLEPAE 600 VRHQDSSFAH 610 KPQASGGQEE 620 APNPPSAQAH 630 QLAAAQPENH 640 ASAFPRARRQ 650 GVSVLRKRYS 660 EPVSLGSAQS 670 PPLSPLALGI 680 KEHELVTGLA 690 QFNLQGSQGM 700 EETSQLTLSD 710 FSPMELESVG 720 HRGPQSLSAS 730 SSSLTPMGRD 740 ALGSLSPALE 750 DGKAAPDEPG 760 SAALGSVGSS 770 DPENKDPRPL 780 FCISDTTDCS 790 LTLDCSEGTD 800 SRPRGGDPEE 810 GGEGDGSMSS 820 GVGEMGDSQV 830 SSNPTSSPPG 840 EAPAPVSVDS 850 EPSCKGGLPR 860 DKPTKRKDVV 870 APKRGSLKEA 880 SPGASKPGSA 890 RRSQGAVAKS 900 VRTLTASENE 910 SMRKVMPITK 920 SSRGAGWRRP 930 ELSSRGPSQN 940 PPSSTDTVWS 950 RQNSVRRAST 960 GAEEQRLPRG 970 SSGSSSTRPG 980 RDVPLQPRGS 990 FKKPSAKPLR 1000 NLPRQKPEEN 1010 KTCRAHSEGP 1020 ESPKEEPKTP 1030 SVPSVPHELP 1040 RVPSFARNTV 1050 ASSSRSMRTD 1060 LPPVAKAPGI 1070 TRTVSQRQLR 1080 VKGDPEDAAP 1090 KDSSTLRRAS 1100 SARAPKKRPE 1110 SAEGPSANTE 1120 APLKARGAGE 1130 RASLRRKDSS 1140 RTTLGRILNP LRK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005884	actin filament
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005881	cytoplasmic microtubule
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005874	microtubule
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0030041	actin filament polymerization
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0090161	Golgi ribbon formation
Biological Process	GO:0043149	stress fiber assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.