Search Results

Overview

Uniprot ID	Q9C0F0
Protein Name	Putative Polycomb group protein ASXL3
Gene Name	ASXL3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1789	LQTTSVGKTAPERNV

Function

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity)

Protein Sequence

10 MKDKRKKKDR 20 TWAEAARLAL 30 EKHPNSPMTA 40 KQILEVIQKE 50 GLKETSGTSP 60 LACLNAMLHT 70 NTRIGDGTFF 80 KIPGKSGLYA 90 LKKEESSCPA 100 DGTLDLVCES 110 ELDGTDMAEA 120 NAHGEENGVC 130 SKQVTDEASS 140 TRDSSLTNTA 150 VQSKLVSSFQ 160 QHTKKALKQA 170 LRQQQKRRNG 180 VSMMVNKTVP 190 RVVLTPLKVS 200 DEQSDSPSGS 210 ESKNGEADSS 220 DKEMKHGQKS 230 PTGKQTSQHL 240 KRLKKSGLGH 250 LKWTKAEDID 260 IETPGSILVN 270 TNLRALINKH 280 TFASLPQHFQ 290 QYLLLLLPEV 300 DRQMGSDGIL 310 RLSTSALNNE 320 FFAYAAQGWK 330 QRLAEGEFTP 340 EMQLRIRQEI 350 EKEKKTEPWK 360 EKFFERFYGE 370 KLGMSREESV 380 KLTTGPNNAG 390 AQSSSSCGTS 400 GLPVSAQTAL 410 AEQQPKSMKS 420 PASPEPGFCA 430 TLCPMVEIPP 440 KDIMAELESE 450 DILIPEESVI 460 QEEIAEEVET 470 SICECQDENH 480 KTIPEFSEEA 490 ESLTNSHEEP 500 QIAPPEDNLE 510 SCVMMNDVLE 520 TLPHIEVKIE 530 GKSESPQEEM 540 TVVIDQLEVC 550 DSLIPSTSSM 560 THVSDTEHKE 570 SETAVETSTP 580 KIKTGSSSLE 590 GQFPNEGIAI 600 DMELQSDPEE 610 QLSENACISE 620 TSFSSESPEG 630 ACTSLPSPGG 640 ETQSTSEESC 650 TPASLETTFC 660 SEVSSTENTD 670 KYNQRNSTDE 680 NFHASLMSEI 690 SPISTSPEIS 700 EASLMSNLPL 710 TSEASPVSNL 720 PLTSETSPMS 730 DLPLTSETSS 740 VSSMLLTSET 750 TFVSSLPLPS 760 ETSPISNSSI 770 NERMAHQQRK 780 SPSVSEEPLS 790 PQKDESSATA 800 KPLGENLTSQ 810 QKNLSNTPEP 820 IIMSSSSIAP 830 EAFPSEDLHN 840 KTLSQQTCKS 850 HVDTEKPYPA 860 SIPELASTEM 870 IKVKNHSVLQ 880 RTEKKVLPSP 890 LELSVFSEGT 900 DNKGNELPSA 910 KLQDKQYISS 920 VDKAPFSEGS 930 RNKTHKQGST 940 QSRLETSHTS 950 KSSEPSKSPD 960 GIRNESRDSE 970 ISKRKTAEQH 980 SFGICKEKRA 990 RIEDDQSTRN 1000 ISSSSPPEKE 1010 QPPREEPRVP 1020 PLKIQLSKIG 1030 PPFIIKSQPV 1040 SKPESRASTS 1050 TSVSGGRNTG 1060 ARTLADIKAR 1070 AQQARAQREA 1080 AAAAAVAAAA 1090 SIVSGAMGSP 1100 GEGGKTRTLA 1110 HIKEQTKAKL 1120 FAKHQARAHL 1130 FQTSKETRLP 1140 PPLSSKEGPP 1150 NLEVSSTPET 1160 KMEGSTGVII 1170 VNPNCRSPSN 1180 KSAHLRETTT 1190 VLQQSLNPSK 1200 LPETATDLSV 1210 HSSDENIPVS 1220 HLSEKIVSST 1230 SSENSSVPML 1240 FNKNSVPVSV 1250 CSTAISGAIK 1260 EHPFVSSVDK 1270 SSVLMSVDSA 1280 NTTISACNIS 1290 MLKTIQGTDT 1300 PCIAIIPKCI 1310 ESTPISATTE 1320 GSSISSSMDD 1330 KQLLISSSSA 1340 SNLVSTQYTS 1350 VPTPSIGNNL 1360 PNLSTSSVLI 1370 PPMGINNRFP 1380 SEKIAIPGSE 1390 EQATVSMGTT 1400 VRAALSCSDS 1410 VAVTDSLVAH 1420 PTVAMFTGNM 1430 LTINSYDSPP 1440 KLSAESLDKN 1450 SGPRNRADNS 1460 GKPQQPPGGF 1470 APAAINRSIP 1480 CKVIVDHSTT 1490 LTSSLSLTVS 1500 VESSEASLDL 1510 QGRPVRTEAS 1520 VQPVACPQVS 1530 VISRPEPVAN 1540 EGIDHSSTFI 1550 AASAAKQDSK 1560 TLPATCTSLR 1570 ELPLVPDKLN 1580 EPTAPSHNFA 1590 EQARGPAPFK 1600 SEADTTCSNQ 1610 YNPSNRICWN 1620 DDGMRSTGQP 1630 LVTHSGSSKQ 1640 KEYLEQSCPK 1650 AIKTEHANYL 1660 NVSELHPRNL 1670 VTNVALPVKS 1680 ELHEADKGFR 1690 MDTEDFPGPE 1700 LPPPAAEGAS 1710 SVQQTQNMKA 1720 STSSPMEEAI 1730 SLATDALKRV 1740 PGAGSSGCRL 1750 SSVEANNPLV 1760 TQLLQGNLPL 1770 EKVLPQPRLG 1780 AKLEINRLPL 1790 PLQTTSVGKT 1800 APERNVEIPP 1810 SSPNPDGKGY 1820 LAGTLAPLQM 1830 RKRENHPKKR 1840 VARTVGEHTQ 1850 VKCEPGKLLV 1860 EPDVKGVPCV 1870 ISSGISQLGH 1880 SQPFKQEWLN 1890 KHSMQNRIVH 1900 SPEVKQQKRL 1910 LPSCSFQQNL 1920 FHVDKNGGFH 1930 TDAGTSHRQQ 1940 FYQMPVAARG 1950 PIPTAALLQA 1960 SSKTPVGCNA 1970 FAFNRHLEQK 1980 GLGEVSLSSA 1990 PHQLRLANML 2000 SPNMPMKEGD 2010 EVGGTAHTMP 2020 NKALVHPPPP 2030 PPPPPPPPLA 2040 LPPPPPPPPP 2050 LPPPLPNAEV 2060 PSDQKQPPVT 2070 METTKRLSWP 2080 QSTGICSNIK 2090 SEPLSFEEGL 2100 SSSCELGMKQ 2110 VSYDQNEMKE 2120 QLKAFALKSA 2130 DFSSYLLSEP 2140 QKPFTQLAAQ 2150 KMQVQQQQQL 2160 CGNYPTIHFG 2170 STSFKRAASA 2180 IEKSIGILGS 2190 GSNPATGLSG 2200 QNAQMPVQNF 2210 ADSSNADELE 2220 LKCSCRLKAM 2230 IVCKGCGAFC 2240 HDDCIGPSKL CVACLVVR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035517	PR-DUB complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II

Reference

PMID: N/A