Search Results

Overview

Uniprot ID	Q9C0H9
Protein Name	SRC kinase signaling inhibitor 1
Gene Name	SRCIN1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
526	FAESPGGKTRSAGSA

Function

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance

Protein Sequence

10 MGNAPSQDPE 20 RSSPPMLSAD 30 DAEYPREYRT 40 LGGGGGGGSG 50 GRRFSNVGLV 60 HTSERRHTVI 70 AAQSLEALSG 80 LQKADADRKR 90 DAFMDHLKSK 100 YPQHALALRG 110 QQDRMREQPN 120 YWSFKTRSSR 130 HTQGAQPGLA 140 DQAAKLSYAS 150 AESLETMSEA 160 ELPLGFSRMN 170 RFRQSLPLSR 180 SASQTKLRSP 190 GVLFLQFGEE 200 TRRVHITHEV 210 SSLDTLHALI 220 AHMFPQKLTM 230 GMLKSPNTAI 240 LIKDEARNVF 250 YELEDVRDIQ 260 DRSIIKIYRK 270 EPLYAAFPGS 280 HLTNGDLRRE 290 MVYASRESSP 300 TRRLNNLSPA 310 PHLASGSPPP 320 GLPSGLPSGL 330 QSGSPSRSRL 340 SYAGGRPPSY 350 AGSPVHHAAE 360 RLGGAPAAQG 370 VSPSPSAILE 380 RRDVKPDEDL 390 ASKAGGMVLV 400 KGEGLYADPY 410 GLLHEGRLSL 420 AAAAGDPFAY 430 PGAGGLYKRG 440 SVRSLSTYSA 450 AALQSDLEDS 460 LYKAAGGGGP 470 LYGDGYGFRL 480 PPSSPQKLAD 490 VAAPPGGPPP 500 PHSPYSGPPS 510 RGSPVRQSFR 520 KDSGSSSVFA 530 ESPGGKTRSA 540 GSASTAGAPP 550 SELFPGPGER 560 SLVGFGPPVP 570 AKDTETRERM 580 EAMEKQIASL 590 TGLVQSALLR 600 GSEPETPSEK 610 IEGSNGAATP 620 SAPCGSGGRS 630 SGATPVSGPP 640 PPSASSTPAG 650 QPTAVSRLQM 660 QLHLRGLQNS 670 ASDLRGQLQQ 680 LRKLQLQNQE 690 SVRALLKRTE 700 AELSMRVSEA 710 ARRQEDPLQR 720 QRTLVEEERL 730 RYLNDEELIT 740 QQLNDLEKSV 750 EKIQRDVSHN 760 HRLVPGPELE 770 EKALVLKQLG 780 ETLTELKAHF 790 PGLQSKMRVV 800 LRVEVEAVKF 810 LKEEPQRLDG 820 LLKRCRGVTD 830 TLAQIRRQVD 840 EGVWPPPNNL 850 LSQSPKKVTA 860 ETDFNKSVDF 870 EMPPPSPPLN 880 LHELSGPAEG 890 ASLTPKGGNP 900 TKGLDTPGKR 910 SVDKAVSVEA 920 AERDWEEKRA 930 ALTQYSAKDI 940 NRLLEETQAE 950 LLKAIPDLDC 960 ASKAHPGPAP 970 TPDHKPPKAP 980 HGQKAAPRTE 990 PSGRRGSDEL 1000 TVPRYRTEKP 1010 SKSPPPPPPR 1020 RSFPSSHGLT 1030 TTRTGEVVVT 1040 SKKDSAFIKK 1050 AESEELEVQK 1060 PQVKLRRAVS 1070 EVARPASTPP 1080 IMASAIKDED 1090 DEDRIIAELE 1100 SGGGSVPPMK 1110 VVTPGASRLK 1120 AAQGQAGSPD 1130 KSKHGKQRAE 1140 YMRIQAQQQA 1150 TKPSKEMSGS 1160 NETSSPVSEK 1170 PSASRTSIPV 1180 LTSFGARNSS ISF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0030424	axon
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0006887	exocytosis
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.