Search Results

Overview

Uniprot IDQ9C0I1
Protein NameMyotubularin-related protein 12
Gene NameMTMR12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 VGGGGGTKAPKPSFV
597 LLGKRISKLINSSDE

Function

Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity)

Protein Sequence

10 MLGKGVVGGG 20 GGTKAPKPSF 30 VSYVRPEEIH 40 TNEKEVTEKE 50 VTLHLLPGEQ 60 LLCEASTVLK 70 YVQEDSCQHG 80 VYGRLVCTDF 90 KIAFLGDDES 100 ALDNDETQFK 110 NKVIGENDIT 120 LHCVDQIYGV 130 FDEKKKTLFG 140 QLKKYPEKLI 150 IHCKDLRVFQ 160 FCLRYTKEEE 170 VKRIVSGIIH 180 HTQAPKLLKR 190 LFLFSYATAA 200 QNNTVTDPKN 210 HTVMFDTLKD 220 WCWELERTKG 230 NMKYKAVSVN 240 EGYKVCERLP 250 AYFVVPTPLP 260 EENVQRFQGH 270 GIPIWCWSCH 280 NGSALLKMSA 290 LPKEQDDGIL 300 QIQKSFLDGI 310 YKTIHRPPYE 320 IVKTEDLSSN 330 FLSLQEIQTA 340 YSKFKQLFLI 350 DNSTEFWDTD 360 IKWFSLLESS 370 SWLDIIRRCL 380 KKAIEITECM 390 EAQNMNVLLL 400 EENASDLCCL 410 ISSLVQLMMD 420 PHCRTRIGFQ 430 SLIQKEWVMG 440 GHCFLDRCNH 450 LRQNDKEEVP 460 VFLLFLDCVW 470 QLVHQHPPAF 480 EFTETYLTVL 490 SDSLYIPIFS 500 TFFFNSPHQK 510 DTNMGREGQD 520 TQSKPLNLLT 530 VWDWSVQFEP 540 KAQTLLKNPL 550 YVEKPKLDKG 560 QRKGMRFKHQ 570 RQLSLPLTQS 580 KSSPKRGFFR 590 EETDHLIKNL 600 LGKRISKLIN 610 SSDELQDNFR 620 EFYDSWHSKS 630 TDYHGLLLPH 640 IEGPEIKVWA 650 QRYLRWIPEA 660 QILGGGQVAT 670 LSKLLEMMEE 680 VQSLQEKIDE 690 RHHSQQAPQA 700 EAPCLLRNSA 710 RLSSLFPFAL 720 LQRHSSKPVL 730 PTSGWKALGD 740 EDDLAKREDE FVDLGDV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0016529 sarcoplasmic reticulum
Molecular Function GO:0019211 phosphatase activator activity
Biological Process GO:0006661 phosphatidylinositol biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.