Search Results

Overview

Uniprot IDQ9C0J8
Protein Namepre-mRNA 3' end processing protein WDR33
Gene NameWDR33
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1023 PDDFHPDKRFGHRLR
1044 GPLPQEEKWRRGGPG
1161 GTPRGGRKGLLPTPD
1232 MASLPPRKRPWHDGP
248 RGHGADVKCVDWHPT
46 QQLTFDGKRMRKAVN
906 PIPFQQQKTPLLGDG
956 GQGPGPNKGDSRGPP

Function

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends

Protein Sequence

10 MATEIGSPPR 20 FFHMPRFQHQ 30 APRQLFYKRP 40 DFAQQQAMQQ 50 LTFDGKRMRK 60 AVNRKTIDYN 70 PSVIKYLENR 80 IWQRDQRDMR 90 AIQPDAGYYN 100 DLVPPIGMLN 110 NPMNAVTTKF 120 VRTSTNKVKC 130 PVFVVRWTPE 140 GRRLVTGASS 150 GEFTLWNGLT 160 FNFETILQAH 170 DSPVRAMTWS 180 HNDMWMLTAD 190 HGGYVKYWQS 200 NMNNVKMFQA 210 HKEAIREASF 220 SPTDNKFATC 230 SDDGTVRIWD 240 FLRCHEERIL 250 RGHGADVKCV 260 DWHPTKGLVV 270 SGSKDSQQPI 280 KFWDPKTGQS 290 LATLHAHKNT 300 VMEVKLNLNG 310 NWLLTASRDH 320 LCKLFDIRNL 330 KEELQVFRGH 340 KKEATAVAWH 350 PVHEGLFASG 360 GSDGSLLFWH 370 VGVEKEVGGM 380 EMAHEGMIWS 390 LAWHPLGHIL 400 CSGSNDHTSK 410 FWTRNRPGDK 420 MRDRYNLNLL 430 PGMSEDGVEY 440 DDLEPNSLAV 450 IPGMGIPEQL 460 KLAMEQEQMG 470 KDESNEIEMT 480 IPGLDWGMEE 490 VMQKDQKKVP 500 QKKVPYAKPI 510 PAQFQQAWMQ 520 NKVPIPAPNE 530 VLNDRKEDIK 540 LEEKKKTQAE 550 IEQEMATLQY 560 TNPQLLEQLK 570 IERLAQKQVE 580 QIQPPPSSGT 590 PLLGPQPFPG 600 QGPMSQIPQG 610 FQQPHPSQQM 620 PMNMAQMGPP 630 GPQGQFRPPG 640 PQGQMGPQGP 650 PLHQGGGGPQ 660 GFMGPQGPQG 670 PPQGLPRPQD 680 MHGPQGMQRH 690 PGPHGPLGPQ 700 GPPGPQGSSG 710 PQGHMGPQGP 720 PGPQGHIGPQ 730 GPPGPQGHLG 740 PQGPPGTQGM 750 QGPPGPRGMQ 760 GPPHPHGIQG 770 GPGSQGIQGP 780 VSQGPLMGLN 790 PRGMQGPPGP 800 RENQGPAPQG 810 MIMGHPPQEM 820 RGPHPPGGLL 830 GHGPQEMRGP 840 QEIRGMQGPP 850 PQGSMLGPPQ 860 ELRGPPGSQS 870 QQGPPQGSLG 880 PPPQGGMQGP 890 PGPQGQQNPA 900 RGPHPSQGPI 910 PFQQQKTPLL 920 GDGPRAPFNQ 930 EGQSTGPPPL 940 IPGLGQQGAQ 950 GRIPPLNPGQ 960 GPGPNKGDSR 970 GPPNHHMGPM 980 SERRHEQSGG 990 PEHGPERGPF 1000 RGGQDCRGPP 1010 DRRGPHPDFP 1020 DDFSRPDDFH 1030 PDKRFGHRLR 1040 EFEGRGGPLP 1050 QEEKWRRGGP 1060 GPPFPPDHRE 1070 FSEGDGRGAA 1080 RGPPGAWEGR 1090 RPGDERFPRD 1100 PEDPRFRGRR 1110 EESFRRGAPP 1120 RHEGRAPPRG 1130 RDGFPGPEDF 1140 GPEENFDASE 1150 EAARGRDLRG 1160 RGRGTPRGGR 1170 KGLLPTPDEF 1180 PRFEGGRKPD 1190 SWDGNREPGP 1200 GHEHFRDTPR 1210 PDHPPHDGHS 1220 PASRERSSSL 1230 QGMDMASLPP 1240 RKRPWHDGPG 1250 TSEHREMEAP 1260 GGPSEDRGGK 1270 GRGGPGPAQR 1280 VPKSGRSSSL 1290 DGEHHDGYHR 1300 DEPFGGPPGS 1310 GTPSRGGRSG 1320 SNWGRGSNMN 1330 SGPPRRGASR GGGRGR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006301 DNA damage tolerance
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.