Search Results
Overview
| Uniprot ID | Q9C0K0 |
|---|---|
| Protein Name | B-cell lymphoma/leukemia 11B |
| Gene Name | BCL11B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 806 | EYCGKVFKNCSNLTV |
| 838 | YACAQSSKLTRHMKT |
Function
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity)
Protein Sequence
10
MSRRKQGNPQ
20
HLSQRELITP
30
EADHVEAAIL
40
EEDEGLEIEE
50
PSGLGLMVGG
60
PDPDLLTCGQ
70
CQMNFPLGDI
80
LVFIEHKRKQ
90
CGGSLGACYD
100
KALDKDSPPP
110
SSRSELRKVS
120
EPVEIGIQVT
130
PDEDDHLLSP
140
TKGICPKQEN
150
IAGPCRPAQL
160
PAVAPIAASS
170
HPHSSVITSP
180
LRALGALPPC
190
LPLPCCSARP
200
VSGDGTQGEG
210
QTEAPFGCQC
220
QLSGKDEPSS
230
YICTTCKQPF
240
NSAWFLLQHA
250
QNTHGFRIYL
260
EPGPASSSLT
270
PRLTIPPPLG
280
PEAVAQSPLM
290
NFLGDSNPFN
300
LLRMTGPILR
310
DHPGFGEGRL
320
PGTPPLFSPP
330
PRHHLDPHRL
340
SAEEMGLVAQ
350
HPSAFDRVMR
360
LNPMAIDSPA
370
MDFSRRLREL
380
AGNSSTPPPV
390
SPGRGNPMHR
400
LLNPFQPSPK
410
SPFLSTPPLP
420
PMPPGGTPPP
430
QPPAKSKSCE
440
FCGKTFKFQS
450
NLIVHRRSHT
460
GEKPYKCQLC
470
DHACSQASKL
480
KRHMKTHMHK
490
AGSLAGRSDD
500
GLSAASSPEP
510
GTSELAGEGL
520
KAADGDFRHH
530
ESDPSLGHEP
540
EEEDEEEEEE
550
EEELLLENES
560
RPESSFSMDS
570
ELSRNRENGG
580
GGVPGVPGAG
590
GGAAKALADE
600
KALVLGKVME
610
NVGLGALPQY
620
GELLADKQKR
630
GAFLKRAAGG
640
GDAGDDDDAG
650
GCGDAGAGGA
660
VNGRGGGFAP
670
GTEPFPGLFP
680
RKPAPLPSPG
690
LNSAAKRIKV
700
EKDLELPPAA
710
LIPSENVYSQ
720
WLVGYAASRH
730
FMKDPFLGFT
740
DARQSPFATS
750
SEHSSENGSL
760
RFSTPPGDLL
770
DGGLSGRSGT
780
ASGGSTPHLG
790
GPGPGRPSSK
800
EGRRSDTCEY
810
CGKVFKNCSN
820
LTVHRRSHTG
830
ERPYKCELCN
840
YACAQSSKLT
850
RHMKTHGQIG
860
KEVYRCDICQ
870
MPFSVYSTLE
880
KHMKKWHGEH
890
LLTNDVKIEQ
AERS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016514 | SWI/SNF complex |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035701 | hematopoietic stem cell migration |
| Biological Process | GO:0097535 | lymphoid lineage cell migration into thymus |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
PMID: N/A