Search Results

Overview

Uniprot IDQ9CPQ8
Protein NameATP synthase F(0) complex subunit g, mitochondrial
Gene NameAtp5mg
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
11 FIRNFAEKAPSMVAA
24 AAAVTYSKPRLATFW
54 PTAIQSVKKIIQSAK
55 TAIQSVKKIIQSAKT
61 KKIIQSAKTGSFKHL
66 SAKTGSFKHLTVKEA

Function

Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)

Protein Sequence

10 MAKFIRNFAE 20 KAPSMVAAAV 30 TYSKPRLATF 40 WHYAKVELVP 50 PTPAEIPTAI 60 QSVKKIIQSA 70 KTGSFKHLTV 80 KEAVLNGLVA 90 TEVWMWFYIG 100 EIIGKRGIVG YDV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0008553 P-type proton-exporting transporter activity
Biological Process GO:0015986 proton motive force-driven ATP synthesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.