Search Results

Overview

Uniprot IDQ9CQ62
Protein Name2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Gene NameDecr1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
106 TAEEISSKTGNKVHA
110 ISSKTGNKVHAIRCD
185 EIGKQLIKAQKGAAF
244 IIQPGPIKTKGAFSR
260 DPTGRFEKEMIDRIP
42 SKDAPQSKFFQPVLK
97 SRNIDVLKATAEEIS

Function

Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Acts primarily on polyunsaturated fatty acids. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally

Protein Sequence

10 MALLGRAFFA 20 GVSRLPCDPG 30 PQRFFSFGTK 40 TLYQSKDAPQ 50 SKFFQPVLKP 60 MLPPDAFQGK 70 VAFITGGGTG 80 LGKAMTTFLS 90 TLGAQCVIAS 100 RNIDVLKATA 110 EEISSKTGNK 120 VHAIRCDVRD 130 PDMVHNTVLE 140 LIKVAGHPDV 150 VINNAAGNFI 160 SPSERLTPNG 170 WKTITDIVLN 180 GTAYVTLEIG 190 KQLIKAQKGA 200 AFLAITTIYA 210 ESGSGFVMPS 220 SSAKSGVEAM 230 NKSLAAEWGR 240 YGMRFNIIQP 250 GPIKTKGAFS 260 RLDPTGRFEK 270 EMIDRIPCGR 280 LGTMEELANL 290 ATFLCSDYAS 300 WINGAVIRFD 310 GGEEVFLSGE 320 FNSLKKVTKE 330 EWDIIEGLIR KTKGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0070402 NADPH binding
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.