Search Results

Overview

Uniprot ID	Q9CQA3
Protein Name	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene Name	Sdhb
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
125	RIDTDLSKVSKIYPL
235	FTEERLAKLQDPFSV
263	PKGLNPGKAIAEIKK
53	IYRWDPDKTGDKPRM
82	LDALIKIKNEVDSTL

Function

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)

Protein Sequence

10 MAATVGVSLK 20 RGFPAAVLGR 30 VGLQFQACRG 40 AQTAAAAAPR 50 IKKFAIYRWD 60 PDKTGDKPRM 70 QTYEVDLNKC 80 GPMVLDALIK 90 IKNEVDSTLT 100 FRRSCREGIC 110 GSCAMNINGG 120 NTLACTRRID 130 TDLSKVSKIY 140 PLPHMYVIKD 150 LVPDLSNFYA 160 QYKSIEPYLK 170 KKDESQEGKQ 180 QYLQSIEDRE 190 KLDGLYECIL 200 CACCSTSCPS 210 YWWNGDKYLG 220 PAVLMQAYRW 230 MIDSRDDFTE 240 ERLAKLQDPF 250 SVYRCHTIMN 260 CTQTCPKGLN 270 PGKAIAEIKK 280 MMATYKEKRA LA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045273	respiratory chain complex II (succinate dehydrogenase)
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0051538	3 iron, 4 sulfur cluster binding
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008177	succinate dehydrogenase (quinone) activity
Molecular Function	GO:0048039	ubiquinone binding
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0006121	mitochondrial electron transport, succinate to ubiquinone
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:0022904	respiratory electron transport chain
Biological Process	GO:0006105	succinate metabolic process
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.