Overview
| Uniprot ID | Q9CQF4 |
|---|
| Protein Name | Mitochondrial transcription rescue factor 1 |
|---|
| Gene Name | Mtres1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 158 |
GLDVGRNKVEDAFYK |
Function
Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability. Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue
Protein Sequence
10
MAVPGVRLLT
20
GALRKPDAWT
30
RLWGVIQGTS
40
SHKLCASWNR
50
YLYFSSTKLN
60
TSNYKTLFRN
70
IFSLRLPELL
80
VSPECYFPFS
90
IRLKSNINSK
100
KSTKKTLQKE
110
ADEEDSDEET
120
SYPERSEQEE
130
ELESEPGVAK
140
DYKDLEKVVQ
150
SFRYDVILKT
160
GLDVGRNKVE
170
DAFYKGELRL
180
NGEKLWKKSR
190
TVKVGDTLDL
200
ITGENKETGT
210
EVVMRILLKK
220
VYEEKTENDK
230
HRVVLRRWKS
240
LKLPKKTLSK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0043023 |
ribosomal large subunit binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000049 |
tRNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:1903108 |
regulation of mitochondrial transcription |
| Biological Process |
GO:0072344 |
rescue of stalled cytosolic ribosome |
| Biological Process |
GO:7770016 |
rescue of stalled mitochondrial ribosome |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.