Search Results
Overview
| Uniprot ID | Q9CQN1 |
|---|---|
| Protein Name | Heat shock protein 75 kDa, mitochondrial |
| Gene Name | Trap1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 98 | EFQAETKKLLDIVAR |
Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA
Protein Sequence
10
MACELRAVLL
20
WGRGLQTVLR
30
APALAGVRRG
40
KPVLHLQKTT
50
VQFRGPTQSL
60
ASGISAGQLY
70
STQAAEDKEE
80
ESLHSIISNT
90
EAVRGSVSKH
100
EFQAETKKLL
110
DIVARSLYSE
120
KEVFIRELIS
130
NASDALEKLR
140
HKLVCEGQVL
150
PEMEIHLQTD
160
AKKGTITIQD
170
TGIGMTQEEL
180
VSNLGTIARS
190
GSKAFLEALQ
200
NQAETSSKII
210
GQFGVGFYSA
220
FMVADKVEVY
230
SRSAAPESPG
240
YQWLSDGSGV
250
FEIAEASGVR
260
PGTKIIIHLK
270
SDCKDFASES
280
RVQDVVTKYS
290
NFVSFPLYLN
300
GKRINTLQAI
310
WMMDPKDISE
320
FQHEEFYRYI
330
AQAYDKPRFT
340
LHYKTDAPLN
350
IRSIFYVPEM
360
KPSMFDVSRE
370
LGSSVALYSR
380
KVLIQTKAAD
390
ILPKWLRFIR
400
GVVDSEDIPL
410
NLSRELLQES
420
ALIRKLRDVL
430
QQRLIKFFID
440
QSKKDAEKYA
450
KFFEDYGLFM
460
REGIVTTAEQ
470
DIKEDIAKLL
480
RYESSALPAG
490
QLTSLPDYAS
500
RMQAGTRNIY
510
YLCAPNRHLA
520
EHSPYYEAMK
530
QKHTEVLFCY
540
EQFDELTLLH
550
LREFDKKKLI
560
SVETDIVVDH
570
YKEEKFEDTS
580
PADERLSEKE
590
TEDLMAWMRN
600
ALGSRVTNVK
610
VTFRLDTHPA
620
MVTVLEMGAA
630
RHFLRMQQLA
640
KTQEERAQLL
650
QPTLEINPRH
660
TLIKKLCQLR
670
ESEPELAQLL
680
VDQIYENAMI
690
AAGLVDDPRA
700
MVGRLNDLLV
KVLEKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1901856 | negative regulation of cellular respiration |
| Biological Process | GO:1903751 | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0009386 | translational attenuation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.