Search Results
Overview
| Uniprot ID | Q9CQX8 |
|---|---|
| Protein Name | Alpha-ketoglutarate dehydrogenase component 4 |
| Gene Name | Kgd4 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 16 | TRVVQVVKPHAPLIK |
| 86 | LPQKYRRKPMSQEEM |
Function
Molecular adapter that is necessary to form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC)
Protein Sequence
10
MGSKMASATR
20
VVQVVKPHAP
30
LIKFPNRRDK
40
PKLSASEALG
50
SAALPSHSSA
60
ISQHSKGSTS
70
PDLLMHQGPP
80
DTAEIIKSLP
90
QKYRRKPMSQ
100
EEMEFIQRGG
PE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045252 | oxoglutarate dehydrogenase complex |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.