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Overview

Uniprot ID	Q9CRB9
Protein Name	MICOS complex subunit Mic19
Gene Name	Chchd3
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
157	ERSSEFYKVTTEEYQ
76	ELALEQAKKESEHQR

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology

Protein Sequence

10 MGGTASTRRV 20 TFEADENENI 30 TVVKGIRLSE 40 NVIDRMKESS 50 PSGSKSQRYS 60 SVYGASVSDE 70 DLKRRVAEEL 80 ALEQAKKESE 90 HQRRLKQARD 100 LERERAAANE 110 QLTRAVLRER 120 ISSEEERMKA 130 KHLARQLEEK 140 DRVMRKQDAF 150 YKEQLARLEE 160 RSSEFYKVTT 170 EEYQKAAEEV 180 EAKFKRYEYH 190 PVCADLQTKI 200 LQCYRQNTQQ 210 TLSCSALASQ 220 YMHCVNHAKQ SMLEKGG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0061617	MICOS complex
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0019902	phosphatase binding
Biological Process	GO:0042407	cristae formation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007007	inner mitochondrial membrane organization
Biological Process	GO:0008053	mitochondrial fusion

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.