Search Results

Overview

Uniprot IDQ9CW03
Protein NameStructural maintenance of chromosomes protein 3
Gene NameSmc3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
106 RRVIGAKKDQYFLDK

Function

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

Protein Sequence

10 MYIKQVIIQG 20 FRSYRDQTIV 30 DPFSSKHNVI 40 VGRNGSGKSN 50 FFYAIQFVLS 60 DEFSHLRPEQ 70 RLALLHEGTG 80 PRVISAFVEI 90 IFDNSDNRLP 100 IDKEEVSLRR 110 VIGAKKDQYF 120 LDKKMVTKND 130 VMNLLESAGF 140 SRSNPYYIVK 150 QGKINQMATA 160 PDSQRLKLLR 170 EVAGTRVYDE 180 RKEESISLMK 190 ETEGKREKIN 200 ELLKYIEERL 210 HTLEEEKEEL 220 AQYQKWDKMR 230 RALEYTIYNQ 240 ELNETRAKLD 250 ELSAKRETSG 260 EKSRQLRDAQ 270 QDARDKMEDI 280 ERQVRELKTK 290 ISAMKEEKEQ 300 LSAERQEQIK 310 QRTKLELKAK 320 DLQDELAGNS 330 EQRKRLLKER 340 QKLLEKIEEK 350 QKELAETEPK 360 FNSVKEKEER 370 GIARLAQATQ 380 ERTDLYAKQG 390 RGSQFTSKEE 400 RDKWIKKELK 410 SLDQAINDKK 420 RQIAAIHKDL 430 EDTEANKEKN 440 LEQYNKLDQD 450 LNEVKARVEE 460 LDRKYYEVKN 470 KKDELQSERN 480 YLWREENAEQ 490 QALAAKREDL 500 EKKQQLLRAA 510 TGKAILNGID 520 SINKVLEHFR 530 RKGINQHVQN 540 GYHGIVMNNF 550 ECEPAFYTCV 560 EVTAGNRLFY 570 HIVDSDEVST 580 KILMEFNKMN 590 LPGEVTFLPL 600 NKLDVRDTAY 610 PETNDAIPMI 620 SKLRYNPRFD 630 KAFKHVFGKT 640 LICRSMEVST 650 QLARAFTMDC 660 ITLEGDQVSH 670 RGALTGGYYD 680 TRKSRLELQK 690 DVRKAEEELG 700 ELEAKLNENL 710 RRNIERINNE 720 IDQLMNQMQQ 730 IETQQRKFKA 740 SRDSILSEMK 750 MLKEKRQQSE 760 KTFMPKQRSL 770 QSLEASLHAM 780 ESTRESLKAE 790 LGTDLLSQLS 800 LEDQKRVDAL 810 NDEIRQLQQE 820 NRQLLNERIK 830 LEGIITRVET 840 YLNENLRKRL 850 DQVEQELNEL 860 RETEGGTVLT 870 ATTSELEAIN 880 KRVKDTMARS 890 EDLDNSIDKT 900 EAGIKELQKS 910 MERWKNMEKE 920 HMDAINHDTK 930 ELEKMTNRQG 940 MLLKKKEECM 950 KKIRELGSLP 960 QEAFEKYQTL 970 SLKQLFRKLE 980 QCNTELKKYS 990 HVNKKALDQF 1000 VNFSEQKEKL 1010 IKRQEELDRG 1020 YKSIMELMNV 1030 LELRKYEAIQ 1040 LTFKQVSKNF 1050 SEVFQKLVPG 1060 GKATLVMKKG 1070 DVEGSQSQDE 1080 GEGSGESERG 1090 SGSQSSVPSV 1100 DQFTGVGIRV 1110 SFTGKQGEMR 1120 EMQQLSGGQK 1130 SLVALALIFA 1140 IQKCDPAPFY 1150 LFDEIDQALD 1160 AQHRKAVSDM 1170 IMELAVHAQF 1180 ITTTFRPELL 1190 ESADKFYGVK 1200 FRNKVSHIDV 1210 ITAEMAKDFV EDDTTHG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0008278 cohesin complex
Cellular Component GO:0000800 lateral element
Cellular Component GO:0030893 meiotic cohesin complex
Cellular Component GO:0030892 mitotic cohesin complex
Cellular Component GO:0097431 mitotic spindle pole
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000795 synaptonemal complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0048487 beta-tubulin binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0000987 cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0070840 dynein complex binding
Molecular Function GO:0036033 mediator complex binding
Molecular Function GO:0046982 protein heterodimerization activity
Biological Process GO:0051301 cell division
Biological Process GO:0006281 DNA repair
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0007062 sister chromatid cohesion
Biological Process GO:0019827 stem cell population maintenance

Reference

[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.