Search Results
Overview
| Uniprot ID | Q9CXD6 |
|---|---|
| Protein Name | Mitochondrial calcium uniporter regulator 1 |
| Gene Name | Mcur1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | CHQLEHRKENLPLSV |
| 253 | TKVRTDTKLNFNLEK |
Function
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex)
Protein Sequence
10
MDSGSVAAER
20
PRRTPSRQRL
30
PSSGCGVPAR
40
PGVSTLPGGR
50
SWLRPRGRAA
60
RASPLLFLLL
70
VPSPRLAATA
80
TATAPRRTLA
90
ERSRPGLVLP
100
AAALGAGRNA
110
LGRLRLGARR
120
VAALASSRRE
130
LSLSAKCHQL
140
EHRKENLPLS
150
VSRQLYFDTH
160
ALVCLLEANG
170
FTIQQAEIIV
180
SALVKITETN
190
MNIIYKDMVS
200
KMQQEIALQQ
210
VLSKIANVKK
220
DMVILEKSEF
230
SALRAENEKI
240
KLELHQLKQQ
250
VMDEVTKVRT
260
DTKLNFNLEK
270
SRVKELYSLN
280
EKKMLELRTE
290
IVSLHAQQDR
300
ALTQTDRKIE
310
TEVAGLKTML
320
EAHKLDTIKY
330
LAGSVFTCLT
340
VALGFYRLWI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0036444 | calcium import into the mitochondrion |
| Biological Process | GO:0070509 | calcium ion import |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0006091 | generation of precursor metabolites and energy |
| Biological Process | GO:0006851 | mitochondrial calcium ion transmembrane transport |
| Biological Process | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| Biological Process | GO:0051291 | protein heterooligomerization |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.