Search Results
Overview
| Uniprot ID | Q9CXW3 |
|---|---|
| Protein Name | Calcyclin-binding protein |
| Gene Name | Cacybp |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 213 | DMKRTINKAWVESRE |
Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity)
Protein Sequence
10
MASVLEELQK
20
DLEEVKVLLE
30
KSTRKRLRDT
40
LTSEKSKIET
50
ELKNKMQQKS
60
QKKPELDNEK
70
PAAVVAPLTT
80
GYTVKISNYG
90
WDQSDKFVKI
100
YITLTGVHQV
110
PTENVQVHFT
120
ERSFDLLVKN
130
LNGKNYSMIV
140
NNLLKPISVE
150
SSSKKVKTDT
160
VIILCRKKAE
170
NTRWDYLTQV
180
EKECKEKEKP
190
SYDTEADPSE
200
GLMNVLKKIY
210
EDGDDDMKRT
220
INKAWVESRE
KQAREDTEF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030877 | beta-catenin destruction complex |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005641 | nuclear envelope lumen |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0019005 | SCF ubiquitin ligase complex |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0055007 | cardiac muscle cell differentiation |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:0060416 | response to growth hormone |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.