Search Results

Overview

Uniprot ID	Q9CZ13
Protein Name	Cytochrome b-c1 complex subunit 1, mitochondrial
Gene Name	Uqcrc1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
102	HLAFKGTKNRPGNAL
138	YLIKALSKDLPKVVE
248	QLLDLAQKHLSSVSR

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:34616041, PubMed:38575788). The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (By similarity)

Protein Sequence

10 MAASAVCRAA 20 CSGTQVLLRT 30 RRSPALLRLP 40 ALRGTATFAQ 50 ALQSVPETQV 60 SILDNGLRVA 70 SEQSSHATCT 80 VGVWIDAGSR 90 YETEKNNGAG 100 YFLEHLAFKG 110 TKNRPGNALE 120 KEVESIGAHL 130 NAYSTREHTA 140 YLIKALSKDL 150 PKVVELLADI 160 VQNSSLEDSQ 170 IEKERDVILR 180 EMQENDASMQ 190 NVVFDYLHAT 200 AFQGTPLAQA 210 VEGPSENVRR 220 LSRTDLTDYL 230 NRHYKAPRMV 240 LAAAGGVEHQ 250 QLLDLAQKHL 260 SSVSRVYEED 270 AVPGLTPCRF 280 TGSEIRHRDD 290 ALPLAHVAIA 300 VEGPGWANPD 310 NVTLQVANAI 320 IGHYDCTYGG 330 GVHLSSPLAS 340 VAVANKLCQS 350 FQTFNISYSD 360 TGLLGAHFVC 370 DAMSIDDMVF 380 FLQGQWMRLC 390 TSATESEVTR 400 GKNILRNALV 410 SHLDGTTPVC 420 EDIGRSLLTY 430 GRRIPLAEWE 440 SRIQEVDAQM 450 LRDICSKYFY 460 DQCPAVAGYG 470 PIEQLPDYNR 480 IRSGMFWLRF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0017087	mitochondrial processing peptidase complex
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0045275	respiratory chain complex III
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0045333	cellular respiration
Biological Process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
Biological Process	GO:0034551	mitochondrial respiratory chain complex III assembly
Biological Process	GO:0006627	protein processing involved in protein targeting to mitochondrion
Biological Process	GO:0014823	response to activity
Biological Process	GO:0043279	response to alkaloid

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.