Search Results
Overview
| Uniprot ID | Q9CZ42 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | Naxd |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | IVPALTSKKHKGQDG |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MAVHACGAAA
20
AVVALLSAAI
30
ALQWSPLYAV
40
LQRALSLHTA
50
HATKDMENLF
60
QLVRNIVPAL
70
TSKKHKGQDG
80
RIGIVGGCQE
90
YTGAPYFAGI
100
SALKVGADLT
110
HVFCAREAAP
120
VIKSYSPELI
130
VHPVLDSSNA
140
VEEVEKWLPR
150
LHALVVGPGL
160
GRDDLLLNNV
170
RGILESTKAR
180
DIPVVIDADG
190
LWLVAQQPAL
200
IHSYHKAILT
210
PNHVEFSRLW
220
EAVLSSPMDS
230
NDLKGSTLKL
240
SQALGNITVV
250
QKGEQDLISN
260
GQQVLVCNQE
270
GSSRRCGGQG
280
DLLSGSLGVM
290
VHWALRAGPE
300
KTNGSSPLLV
310
AAWGACTLTR
320
ECNRQAFQKY
330
GRSTTTTDMI
340
TEVGTAFSRL
FTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Biological Process | GO:0110051 | metabolite repair |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.