Search Results
Overview
| Uniprot ID | Q9CZL5 |
|---|---|
| Protein Name | Pterin-4-alpha-carbinolamine dehydratase 2 |
| Gene Name | Pcbd2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | GLTKRDVKLAQFIEK |
Function
Plays a role in tetrahydrobiopterin biosynthesis which is a co-factor for amino acid hydroxylases (PubMed:15182178). May prevent both the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:24389307). Also acts as a coactivator for HNF1B-dependent transcription (By similarity)
Protein Sequence
10
MVAAAAVAVA
20
AVGARSAGRW
30
LAALRSPGAS
40
RAAMSSDAQW
50
LTAEERDQLI
60
PGLKAAGWSE
70
LSERDAIYKE
80
FSFKNFNQAF
90
GFMSRVALQA
100
EKMNHHPEWF
110
NVYNKVQITL
120
TSHDCGGLTK
130
RDVKLAQFIE
KAAASL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004505 | phenylalanine 4-monooxygenase activity |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006729 | tetrahydrobiopterin biosynthetic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.