Overview
| Uniprot ID | Q9CZS1 |
|---|
| Protein Name | Aldehyde dehydrogenase family 1 member B1, mitochondrial |
|---|
| Gene Name | Aldh1b1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 385 |
LGQKEGAKLLCGGER |
| 431 |
QPLFKFKKIEEVIQR |
Function
Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo
Protein Sequence
10
MLTARLLLPR
20
LLCLQGRTTS
30
YSTAAALPNP
40
IPNPEICYNK
50
LFINNEWHDA
60
VSKKTFPTVN
70
PTTGEVIGHV
80
AEGDRADVDL
90
AVKAAREAFR
100
LGSPWRRMDA
110
SERGRLLNRL
120
ADLVERDRVY
130
LASLETLDNG
140
KPFQESYVLD
150
LDEVIKVYRY
160
FAGWADKWHG
170
KTIPMDGEHF
180
CFTRHEPVGV
190
CGQIIPWNFP
200
LVMQGWKLAP
210
ALATGNTVVM
220
KVAEQTPLSA
230
LYLASLIKEA
240
GFPPGVVNII
250
TGYGPTAGAA
260
IAQHMDVDKV
270
AFTGSTEVGH
280
LIQKAAGESN
290
LKRVTLELGG
300
KSPSIVLADA
310
DMEHAVDQCH
320
EALFFNMGQC
330
CCAGSRTFVE
340
ESIYREFLER
350
TVEKAKQRKV
360
GNPFELDTQQ
370
GPQVDKEQFE
380
RILGYIRLGQ
390
KEGAKLLCGG
400
ERLGERGFFI
410
KPTVFGDVQD
420
GMRIAKEEIF
430
GPVQPLFKFK
440
KIEEVIQRAN
450
NTRYGLAAAV
460
FTRDLDKAIY
470
FTQALQAGTV
480
WVNTYNIVTC
490
HTPFGGFKES
500
GNGRELGEDG
510
LRAYTEVKTV
TIKVPEKNS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0004029 |
aldehyde dehydrogenase (NAD+) activity |
| Biological Process |
GO:0006081 |
aldehyde metabolic process |
| Biological Process |
GO:0006068 |
ethanol catabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.