Search Results
Overview
| Uniprot ID | Q9CZU6 |
|---|---|
| Protein Name | Citrate synthase, mitochondrial |
| Gene Name | Cs |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | YSIPECQKMLPKAKG |
| 215 | KLPCVAAKIYRNLYR |
| 321 | QLQKEVGKDVSDEKL |
| 327 | GKDVSDEKLRDYIWN |
| 366 | CQREFALKHLPKDPM |
| 370 | FALKHLPKDPMFKLV |
| 393 | NILLEQGKAKNPWPN |
| 43 | VLSNLIPKEQARIKT |
| 450 | GFPLERPKSMSTDGL |
| 459 | MSTDGLMKFVDSK** |
| 57 | TFKQQHGKTVVGQIT |
Function
Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate
Protein Sequence
10
MALLTAATRL
20
LGAKNSSCLV
30
LAARHASASS
40
TNLKDVLSNL
50
IPKEQARIKT
60
FKQQHGKTVV
70
GQITVDMMYG
80
GMRGMKGLVY
90
ETSVLDPDEG
100
IRFRGYSIPE
110
CQKMLPKAKG
120
GEEPLPEGLF
130
WLLVTGQMPT
140
EEQVSWLSRE
150
WAKRAALPSH
160
VVTMLDNFPT
170
NLHPMSQLSA
180
AITALNSESN
190
FARAYAEGMN
200
RAKYWELIYE
210
DCMDLIAKLP
220
CVAAKIYRNL
230
YREGSSIGAI
240
DSRLDWSHNF
250
TNMLGYTDPQ
260
FTELMRLYLT
270
IHSDHEGGNV
280
SAHTSHLVGS
290
ALSDPYLSFA
300
AAMNGLAGPL
310
HGLANQEVLV
320
WLTQLQKEVG
330
KDVSDEKLRD
340
YIWNTLNSGR
350
VVPGYGHAVL
360
RKTDPRYSCQ
370
REFALKHLPK
380
DPMFKLVAQL
390
YKIVPNILLE
400
QGKAKNPWPN
410
VDAHSGVLLQ
420
YYGMTEMNYY
430
TVLFGVSRAL
440
GVLAQLIWSR
450
ALGFPLERPK
460
SMSTDGLMKF
VDSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046912 | acyltransferase activity, acyl groups converted into alkyl on transfer |
| Molecular Function | GO:0036440 | citrate synthase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0006101 | citrate metabolic process |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.